{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tran A"],"funding":["National Institute of Allergy and Infectious Diseases","National Center for Advancing Translational Sciences","NCATS NIH HHS","NIAID NIH HHS","University of Maryland","School of Pharmacy, University of Maryland","American Society of Mass Spectrometry","NIGMS NIH HHS"],"pagination":["2322-2333"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8995026"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(9)"],"pubmed_abstract":["There is an unmet need to develop analytical strategies that not only characterize the lipid composition of the viral envelope but also do so on a time scale that would allow for high-throughput analysis. With that in mind, we report the use of atmospheric pressure (AP) matrix-assisted laser desorption/ionization (MALDI) high-resolution mass spectrometry (HRMS) combined with lithium adduct consolidation to profile total lipid extracts rapidly and confidently from enveloped viruses. The use of AP-MALDI reduced the dependency of using a dedicated MALDI mass spectrometer and allowed for interfacing the MALDI source to a mass spectrometer with the desired features, which included high mass resolving power (>100000) and tandem mass spectrometry. AP-MALDI combined with an optimized MALDI matrix "],"journal":["Journal of the American Society for Mass Spectrometry"],"pubmed_title":["Rapid Detection of Viral Envelope Lipids Using Lithium Adducts and AP-MALDI High-Resolution Mass Spectrometry."],"pmcid":["PMC8995026"],"funding_grant_id":["UL1 TR003098","SOP1841-IQB2014","R01 IA109022","R21 AI142377","1UL1TR003098","T32 GM066706","R01 AI109022"],"pubmed_authors":["Monreal IA","Aguilar HC","Jones JW","Tran A","Moskovets E"],"additional_accession":[]},"is_claimable":false,"name":"Rapid Detection of Viral Envelope Lipids Using Lithium Adducts and AP-MALDI High-Resolution Mass Spectrometry.","description":"There is an unmet need to develop analytical strategies that not only characterize the lipid composition of the viral envelope but also do so on a time scale that would allow for high-throughput analysis. With that in mind, we report the use of atmospheric pressure (AP) matrix-assisted laser desorption/ionization (MALDI) high-resolution mass spectrometry (HRMS) combined with lithium adduct consolidation to profile total lipid extracts rapidly and confidently from enveloped viruses. The use of AP-MALDI reduced the dependency of using a dedicated MALDI mass spectrometer and allowed for interfacing the MALDI source to a mass spectrometer with the desired features, which included high mass resolving power (>100000) and tandem mass spectrometry. AP-MALDI combined with an optimized MALDI matrix ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-19T12:55:00.987Z","creation":"2025-04-19T12:55:00.987Z"},"accession":"S-EPMC8995026","cross_references":{"pubmed":["33886294"],"doi":["10.1021/jasms.1c00058"]}}