{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Habibabady ZA"],"funding":["NIAID NIH HHS","NIGMS NIH HHS"],"pagination":["e12729"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8995366"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(2)"],"pubmed_abstract":["Platelet sequestration is a common process during organ reperfusion after transplantation. However, instead of lower platelet counts, when using traditional hemocytometers and light microscopy, we observed physiologically implausible platelet counts in the course of ex-vivo lung and liver xenograft organ perfusion studies. We employed conventional flow cytometry (FC) and imaging FC (AMINS ImageStream X) to investigate the findings and found platelet-sized fragments in the circulation that are mainly derived from red blood cell membranes. We speculate that this erythrocyte fragmentation contributes to anemia during in-vivo organ xenotransplant."],"journal":["Xenotransplantation"],"pubmed_title":["Human erythrocyte fragmentation during ex-vivo pig organ perfusion."],"pmcid":["PMC8995366"],"funding_grant_id":["U19 AI090959","R01 AI153612","R01 GM092804"],"pubmed_authors":["Sendil S","Burdorf L","Elias GF","Pollok F","Irimia D","Azimzadeh AM","Ellett F","Braileanu G","French BM","Sun W","Pierson RN","Habibabady ZA"],"additional_accession":[]},"is_claimable":false,"name":"Human erythrocyte fragmentation during ex-vivo pig organ perfusion.","description":"Platelet sequestration is a common process during organ reperfusion after transplantation. However, instead of lower platelet counts, when using traditional hemocytometers and light microscopy, we observed physiologically implausible platelet counts in the course of ex-vivo lung and liver xenograft organ perfusion studies. We employed conventional flow cytometry (FC) and imaging FC (AMINS ImageStream X) to investigate the findings and found platelet-sized fragments in the circulation that are mainly derived from red blood cell membranes. We speculate that this erythrocyte fragmentation contributes to anemia during in-vivo organ xenotransplant.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T07:34:32.871Z","creation":"2025-04-19T07:34:32.871Z"},"accession":"S-EPMC8995366","cross_references":{"pubmed":["35112383"],"doi":["10.1111/xen.12729"]}}