{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(18)"],"submitter":["Wu ZL"],"pubmed_abstract":["Eleven undescribed <i>ent</i>-kaurane-type diterpenoid acids, namely noueinsiancins A-K (1-11), together with sixteen related known analogs (12-27) were isolated from <i>Nouelia insignis</i> Franch. The chemical structures and absolute configurations of the new compounds were confirmed by the extensive spectroscopic data, electronic circular dichroism (ECD) data analysis and single crystal X-ray diffraction. Additionally, the anti-inflammatory assay was applied to estimate the nitric oxide (NO) inhibitory activities of all compounds by using lipopolysaccharide (LPS)-induced RAW 264.7 cells <i>in vitro</i>. The results revealed that 4-7 and 13-17 significantly inhibited NO production at the concentrations of 2.5 μM, 5.0 μM and 10.0 μM. Meanwhile, compounds 6 and 7 were found to down-regulat"],"journal":["RSC advances"],"pagination":["11155-11163"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8995843"],"repository":["biostudies-literature"],"pubmed_title":["New <i>ent</i>-kaurane diterpenoid acids from <i>Nouelia insignis</i> Franch and their anti-inflammatory activity."],"pmcid":["PMC8995843"],"pubmed_authors":["Zhang WD","Sun ZS","Li HL","Wu ZL","Li JY","Huang PL"],"additional_accession":[]},"is_claimable":false,"name":"New <i>ent</i>-kaurane diterpenoid acids from <i>Nouelia insignis</i> Franch and their anti-inflammatory activity.","description":"Eleven undescribed <i>ent</i>-kaurane-type diterpenoid acids, namely noueinsiancins A-K (1-11), together with sixteen related known analogs (12-27) were isolated from <i>Nouelia insignis</i> Franch. The chemical structures and absolute configurations of the new compounds were confirmed by the extensive spectroscopic data, electronic circular dichroism (ECD) data analysis and single crystal X-ray diffraction. Additionally, the anti-inflammatory assay was applied to estimate the nitric oxide (NO) inhibitory activities of all compounds by using lipopolysaccharide (LPS)-induced RAW 264.7 cells <i>in vitro</i>. The results revealed that 4-7 and 13-17 significantly inhibited NO production at the concentrations of 2.5 μM, 5.0 μM and 10.0 μM. Meanwhile, compounds 6 and 7 were found to down-regulat","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T23:16:38.246Z","creation":"2025-04-04T23:16:38.246Z"},"accession":"S-EPMC8995843","cross_references":{"pubmed":["35425047"],"doi":["10.1039/d2ra01684b"]}}