{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17"],"submitter":["Stumpf J"],"pubmed_abstract":["<h4>Background</h4>Vulnerable dialysis and kidney transplant patients show impaired seroconversion rates compared to medical personnel eight weeks after SARS-CoV-2mRNA vaccination.<h4>Methods</h4>We evaluated six months follow up data in our observational Dia-Vacc study exploring specific cellular (interferon-γ release assay) or/and humoral immune responses after 2x SARS-CoV-2mRNA vaccination in 1205 participants including medical personnel (125 MP), dialysis patients (970 DP) and kidney transplant recipients (110 KTR) with seroconversion (<i>de novo</i> IgA or IgG antibody positivity by ELISA) after eight weeks.<h4>Findings</h4>Six months after vaccination, seroconversion remained positive in 98% of MP, but 91%/87% of DP/KTR (<i>p</i> = 0·005), respectively. Receptor binding domain-IgG (R"],"journal":["The Lancet regional health. Europe"],"pagination":["100371"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8995854"],"repository":["biostudies-literature"],"pubmed_title":["Risk of strong antibody decline in dialysis and transplant patients after SARS-CoV-2mRNA vaccination: Six months data from the observational Dia-Vacc study."],"pmcid":["PMC8995854"],"pubmed_authors":["Muller P","Bast I","Mauer R","Hugo C","Arndt P","Pietzonka A","Pluntke T","Langer T","Schirutschke H","Martin H","Huther J","Paliege A","Siepmann T","Stehr T","Stumpf J","Sradnick J","Frank K","Lindner T","Barnett K","Karger C","Gembardt F","Schwobel J","Grahlert X","Seidel H","Faulhaber-Walter R","Kessel F","Tonn T","Steglich A","Anding-Rost K","Schewe J","Pistrosch F","Kroger H","Anders L","Meistring F","Cerny S","Klimova A","Escher K"],"additional_accession":[]},"is_claimable":false,"name":"Risk of strong antibody decline in dialysis and transplant patients after SARS-CoV-2mRNA vaccination: Six months data from the observational Dia-Vacc study.","description":"<h4>Background</h4>Vulnerable dialysis and kidney transplant patients show impaired seroconversion rates compared to medical personnel eight weeks after SARS-CoV-2mRNA vaccination.<h4>Methods</h4>We evaluated six months follow up data in our observational Dia-Vacc study exploring specific cellular (interferon-γ release assay) or/and humoral immune responses after 2x SARS-CoV-2mRNA vaccination in 1205 participants including medical personnel (125 MP), dialysis patients (970 DP) and kidney transplant recipients (110 KTR) with seroconversion (<i>de novo</i> IgA or IgG antibody positivity by ELISA) after eight weeks.<h4>Findings</h4>Six months after vaccination, seroconversion remained positive in 98% of MP, but 91%/87% of DP/KTR (<i>p</i> = 0·005), respectively. Receptor binding domain-IgG (R","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-05-29T22:22:19.289Z","creation":"2024-11-09T12:48:39.064Z"},"accession":"S-EPMC8995854","cross_references":{"pubmed":["35434688"],"doi":["10.1016/j.lanepe.2022.100371"]}}