biostudies-literatureUnknown17Stumpf J<h4>Background</h4>Vulnerable dialysis and kidney transplant patients show impaired seroconversion rates compared to medical personnel eight weeks after SARS-CoV-2mRNA vaccination.<h4>Methods</h4>We evaluated six months follow up data in our observational Dia-Vacc study exploring specific cellular (interferon-γ release assay) or/and humoral immune responses after 2x SARS-CoV-2mRNA vaccination in 1205 participants including medical personnel (125 MP), dialysis patients (970 DP) and kidney transplant recipients (110 KTR) with seroconversion (<i>de novo</i> IgA or IgG antibody positivity by ELISA) after eight weeks.<h4>Findings</h4>Six months after vaccination, seroconversion remained positive in 98% of MP, but 91%/87% of DP/KTR (<i>p</i> = 0·005), respectively. Receptor binding domain-IgG (RThe Lancet regional health. Europe100371https://www.ebi.ac.uk/biostudies/studies/S-EPMC8995854biostudies-literatureRisk of strong antibody decline in dialysis and transplant patients after SARS-CoV-2mRNA vaccination: Six months data from the observational Dia-Vacc study.PMC8995854Muller PBast IMauer RHugo CArndt PPietzonka APluntke TLanger TSchirutschke HMartin HHuther JPaliege ASiepmann TStehr TStumpf JSradnick JFrank KLindner TBarnett KKarger CGembardt FSchwobel JGrahlert XSeidel HFaulhaber-Walter RKessel FTonn TSteglich AAnding-Rost KSchewe JPistrosch FKroger HAnders LMeistring FCerny SKlimova AEscher KfalseRisk of strong antibody decline in dialysis and transplant patients after SARS-CoV-2mRNA vaccination: Six months data from the observational Dia-Vacc study.<h4>Background</h4>Vulnerable dialysis and kidney transplant patients show impaired seroconversion rates compared to medical personnel eight weeks after SARS-CoV-2mRNA vaccination.<h4>Methods</h4>We evaluated six months follow up data in our observational Dia-Vacc study exploring specific cellular (interferon-γ release assay) or/and humoral immune responses after 2x SARS-CoV-2mRNA vaccination in 1205 participants including medical personnel (125 MP), dialysis patients (970 DP) and kidney transplant recipients (110 KTR) with seroconversion (<i>de novo</i> IgA or IgG antibody positivity by ELISA) after eight weeks.<h4>Findings</h4>Six months after vaccination, seroconversion remained positive in 98% of MP, but 91%/87% of DP/KTR (<i>p</i> = 0·005), respectively. Receptor binding domain-IgG (R2022-01-01T00:00:00Z2022 Jun2025-05-29T22:22:19.289Z2024-11-09T12:48:39.064ZS-EPMC89958543543468810.1016/j.lanepe.2022.100371