{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Singh S"],"funding":["Engineering and Physical Sciences Research Council"],"pagination":["e059847"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8995953"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(4)"],"pubmed_abstract":["<h4>Introduction</h4>Multiparametric MRI (mpMRI) is now widely used to risk stratify men with a suspicion of prostate cancer and identify suspicious regions for biopsy. However, the technique has modest specificity and a high false-positive rate, especially in men with mpMRI scored as indeterminate (3/5) or likely (4/5) to have clinically significant cancer (csPCa) (Gleason ≥3+4). Advanced MRI techniques have emerged which seek to improve this characterisation and could predict biopsy results non-invasively. Before these techniques are translated clinically, robust histological and clinical validation is required.<h4>Methods and analysis</h4>This study aims to clinically validate two advanced MRI techniques in a prospectively recruited cohort of men suspected of prostate cancer. Histologic"],"journal":["BMJ open"],"pubmed_title":["Histo-MRI map study protocol: a prospective cohort study mapping MRI to histology for biomarker validation and prediction of prostate cancer."],"pmcid":["PMC8995953"],"funding_grant_id":["EP/M020533/1","EP/R006032/1"],"pubmed_authors":["Dinneen E","Patel D","Clemente J","Kasivisvanathan V","Moore CM","Atkinson D","Smith L","Haider A","Suman S","Papoutsaki MV","Panagiotaki E","Mathew M","Punwani S","Alexander D","Freeman A","Grussu F","Retter A","Shaw G","Singh S","Mertzanidou T","Grey A","Carter M"],"additional_accession":[]},"is_claimable":false,"name":"Histo-MRI map study protocol: a prospective cohort study mapping MRI to histology for biomarker validation and prediction of prostate cancer.","description":"<h4>Introduction</h4>Multiparametric MRI (mpMRI) is now widely used to risk stratify men with a suspicion of prostate cancer and identify suspicious regions for biopsy. However, the technique has modest specificity and a high false-positive rate, especially in men with mpMRI scored as indeterminate (3/5) or likely (4/5) to have clinically significant cancer (csPCa) (Gleason ≥3+4). Advanced MRI techniques have emerged which seek to improve this characterisation and could predict biopsy results non-invasively. Before these techniques are translated clinically, robust histological and clinical validation is required.<h4>Methods and analysis</h4>This study aims to clinically validate two advanced MRI techniques in a prospectively recruited cohort of men suspected of prostate cancer. Histologic","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-09T23:48:55.154Z","creation":"2025-04-05T22:17:04.965Z"},"accession":"S-EPMC8995953","cross_references":{"pubmed":["35396316"],"doi":["10.1136/bmjopen-2021-059847"]}}