biostudies-literatureSingh SEngineering and Physical Sciences Research Councile059847https://www.ebi.ac.uk/biostudies/studies/S-EPMC8995953biostudies-literatureUnknown12(4)<h4>Introduction</h4>Multiparametric MRI (mpMRI) is now widely used to risk stratify men with a suspicion of prostate cancer and identify suspicious regions for biopsy. However, the technique has modest specificity and a high false-positive rate, especially in men with mpMRI scored as indeterminate (3/5) or likely (4/5) to have clinically significant cancer (csPCa) (Gleason ≥3+4). Advanced MRI techniques have emerged which seek to improve this characterisation and could predict biopsy results non-invasively. Before these techniques are translated clinically, robust histological and clinical validation is required.<h4>Methods and analysis</h4>This study aims to clinically validate two advanced MRI techniques in a prospectively recruited cohort of men suspected of prostate cancer. HistologicBMJ openHisto-MRI map study protocol: a prospective cohort study mapping MRI to histology for biomarker validation and prediction of prostate cancer.PMC8995953EP/M020533/1EP/R006032/1Dinneen EPatel DClemente JKasivisvanathan VMoore CMAtkinson DSmith LHaider ASuman SPapoutsaki MVPanagiotaki EMathew MPunwani SAlexander DFreeman AGrussu FRetter AShaw GSingh SMertzanidou TGrey ACarter MfalseHisto-MRI map study protocol: a prospective cohort study mapping MRI to histology for biomarker validation and prediction of prostate cancer.<h4>Introduction</h4>Multiparametric MRI (mpMRI) is now widely used to risk stratify men with a suspicion of prostate cancer and identify suspicious regions for biopsy. However, the technique has modest specificity and a high false-positive rate, especially in men with mpMRI scored as indeterminate (3/5) or likely (4/5) to have clinically significant cancer (csPCa) (Gleason ≥3+4). Advanced MRI techniques have emerged which seek to improve this characterisation and could predict biopsy results non-invasively. Before these techniques are translated clinically, robust histological and clinical validation is required.<h4>Methods and analysis</h4>This study aims to clinically validate two advanced MRI techniques in a prospectively recruited cohort of men suspected of prostate cancer. Histologic2022-01-01T00:00:00Z2022 Apr2026-05-09T23:48:55.154Z2025-04-05T22:17:04.965ZS-EPMC89959533539631610.1136/bmjopen-2021-059847