{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(4)"],"submitter":["Quintens C"],"pubmed_abstract":["<h4>Objectives</h4>Early switch from intravenous to oral therapy of bioequivalent drugs has major advantages but remains challenging. At our hospital, a basic clinical rule was designed to automatically alert the physician to review potential intravenous to oral switch (IVOS). A rather low acceptance rate was observed. In this study, we aimed to develop, validate and investigate the effect of more advanced clinical rules for IVOS, as part of a centralised pharmacist-led medication review service.<h4>Design and setting</h4>A quasi-experimental study was performed in a large teaching hospital in Belgium using an interrupted time series design.<h4>Intervention</h4>A definite set of 13 criteria for IVOS, focusing on the ability of oral absorption and type of infection, was obtained by literatu"],"journal":["BMJ open"],"pagination":["e053010"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8995958"],"repository":["biostudies-literature"],"pubmed_title":["From basic to advanced computerised intravenous to oral switch for paracetamol and antibiotics: an interrupted time series analysis."],"pmcid":["PMC8995958"],"pubmed_authors":["Declercq P","Coenen M","Quintens C","Peetermans WE","Spriet I","Casteels M"],"additional_accession":[]},"is_claimable":false,"name":"From basic to advanced computerised intravenous to oral switch for paracetamol and antibiotics: an interrupted time series analysis.","description":"<h4>Objectives</h4>Early switch from intravenous to oral therapy of bioequivalent drugs has major advantages but remains challenging. At our hospital, a basic clinical rule was designed to automatically alert the physician to review potential intravenous to oral switch (IVOS). A rather low acceptance rate was observed. In this study, we aimed to develop, validate and investigate the effect of more advanced clinical rules for IVOS, as part of a centralised pharmacist-led medication review service.<h4>Design and setting</h4>A quasi-experimental study was performed in a large teaching hospital in Belgium using an interrupted time series design.<h4>Intervention</h4>A definite set of 13 criteria for IVOS, focusing on the ability of oral absorption and type of infection, was obtained by literatu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-05T22:17:06.933Z","creation":"2025-04-05T22:17:06.933Z"},"accession":"S-EPMC8995958","cross_references":{"pubmed":["35396281"],"doi":["10.1136/bmjopen-2021-053010"]}}