biostudies-literatureUnknown12(4)Quintens C<h4>Objectives</h4>Early switch from intravenous to oral therapy of bioequivalent drugs has major advantages but remains challenging. At our hospital, a basic clinical rule was designed to automatically alert the physician to review potential intravenous to oral switch (IVOS). A rather low acceptance rate was observed. In this study, we aimed to develop, validate and investigate the effect of more advanced clinical rules for IVOS, as part of a centralised pharmacist-led medication review service.<h4>Design and setting</h4>A quasi-experimental study was performed in a large teaching hospital in Belgium using an interrupted time series design.<h4>Intervention</h4>A definite set of 13 criteria for IVOS, focusing on the ability of oral absorption and type of infection, was obtained by literatuBMJ opene053010https://www.ebi.ac.uk/biostudies/studies/S-EPMC8995958biostudies-literatureFrom basic to advanced computerised intravenous to oral switch for paracetamol and antibiotics: an interrupted time series analysis.PMC8995958Declercq PCoenen MQuintens CPeetermans WESpriet ICasteels MfalseFrom basic to advanced computerised intravenous to oral switch for paracetamol and antibiotics: an interrupted time series analysis.<h4>Objectives</h4>Early switch from intravenous to oral therapy of bioequivalent drugs has major advantages but remains challenging. At our hospital, a basic clinical rule was designed to automatically alert the physician to review potential intravenous to oral switch (IVOS). A rather low acceptance rate was observed. In this study, we aimed to develop, validate and investigate the effect of more advanced clinical rules for IVOS, as part of a centralised pharmacist-led medication review service.<h4>Design and setting</h4>A quasi-experimental study was performed in a large teaching hospital in Belgium using an interrupted time series design.<h4>Intervention</h4>A definite set of 13 criteria for IVOS, focusing on the ability of oral absorption and type of infection, was obtained by literatu2022-01-01T00:00:00Z2022 Apr2025-04-05T22:17:06.933Z2025-04-05T22:17:06.933ZS-EPMC89959583539628110.1136/bmjopen-2021-053010