{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye S"],"funding":["Young Scientists Fund","Natural Science Foundation of Shanghai"],"pagination":["43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8996636"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Background
To investigate the alterations of peripheral lymphocyte subpopulations in ovarian cancer patients compared to benign or borderline counterparts. The possible clinicopathological implications were also evaluated.Methods
We enrolled 112 treatment-naive ovarian cancer patients, 14 borderline tumor patients and 44 benign tumor patients between 09/2016 and 01/2019. Flow cytometry was used to measure the peripheral lymphocyte subsets consisting of T cells (CD3+, CD3+CD4+, CD3+CD8+ and CD8+CD28+), regulatory T cells (Tregs, CD4+CD25+CD127-), natural killer cells (NK cells, CD3-CD56+) and B cells (CD19+).Results
Most ovari"],"journal":["Journal of ovarian research"],"pubmed_title":["Peripheral lymphocyte populations in ovarian cancer patients and correlations with clinicopathological features."],"pmcid":["PMC8996636"],"funding_grant_id":["81702558","20ZR1413000"],"pubmed_authors":["Yang H","Zheng Y","Li T","Ye S","Zhang X","Chen W","Ping B","Wu Y","Xiang L"],"additional_accession":[]},"is_claimable":false,"name":"Peripheral lymphocyte populations in ovarian cancer patients and correlations with clinicopathological features.","description":"Background
To investigate the alterations of peripheral lymphocyte subpopulations in ovarian cancer patients compared to benign or borderline counterparts. The possible clinicopathological implications were also evaluated.Methods
We enrolled 112 treatment-naive ovarian cancer patients, 14 borderline tumor patients and 44 benign tumor patients between 09/2016 and 01/2019. Flow cytometry was used to measure the peripheral lymphocyte subsets consisting of T cells (CD3+, CD3+CD4+, CD3+CD8+ and CD8+CD28+), regulatory T cells (Tregs, CD4+CD25+CD127-), natural killer cells (NK cells, CD3-CD56+) and B cells (CD19+).Results
Most ovari","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T12:40:20.543Z","creation":"2025-04-04T12:40:20.543Z"},"accession":"S-EPMC8996636","cross_references":{"pubmed":["35410290"],"doi":["10.1186/s13048-022-00977-3"]}}