biostudies-literatureYe SYoung Scientists FundNatural Science Foundation of Shanghai43https://www.ebi.ac.uk/biostudies/studies/S-EPMC8996636biostudies-literatureUnknown15(1)<h4>Background</h4>To investigate the alterations of peripheral lymphocyte subpopulations in ovarian cancer patients compared to benign or borderline counterparts. The possible clinicopathological implications were also evaluated.<h4>Methods</h4>We enrolled 112 treatment-naive ovarian cancer patients, 14 borderline tumor patients and 44 benign tumor patients between 09/2016 and 01/2019. Flow cytometry was used to measure the peripheral lymphocyte subsets consisting of T cells (CD3⁺, CD3⁺CD4⁺, CD3⁺CD8⁺ and CD8⁺CD28⁺), regulatory T cells (Tregs, CD4⁺CD25⁺CD127^-), natural killer cells (NK cells, CD3^-CD56⁺) and B cells (CD19⁺).<h4>Results</h4>Most ovariJournal of ovarian researchPeripheral lymphocyte populations in ovarian cancer patients and correlations with clinicopathological features.PMC89966368170255820ZR1413000Yang HZheng YLi TYe SZhang XChen WPing BWu YXiang LfalsePeripheral lymphocyte populations in ovarian cancer patients and correlations with clinicopathological features.<h4>Background</h4>To investigate the alterations of peripheral lymphocyte subpopulations in ovarian cancer patients compared to benign or borderline counterparts. The possible clinicopathological implications were also evaluated.<h4>Methods</h4>We enrolled 112 treatment-naive ovarian cancer patients, 14 borderline tumor patients and 44 benign tumor patients between 09/2016 and 01/2019. Flow cytometry was used to measure the peripheral lymphocyte subsets consisting of T cells (CD3⁺, CD3⁺CD4⁺, CD3⁺CD8⁺ and CD8⁺CD28⁺), regulatory T cells (Tregs, CD4⁺CD25⁺CD127^-), natural killer cells (NK cells, CD3^-CD56⁺) and B cells (CD19⁺).<h4>Results</h4>Most ovari2022-01-01T00:00:00Z2022 Apr2025-04-04T12:40:20.543Z2025-04-04T12:40:20.543ZS-EPMC89966363541029010.1186/s13048-022-00977-3