{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61(4)"],"submitter":["Decato BE"],"funding":["Bristol Myers Squibb"],"pubmed_abstract":["<h4>Objective</h4>SSc is a rheumatic autoimmune disease affecting roughly 20 000 people worldwide and characterized by excessive collagen accumulation in the skin and internal organs. Despite the high morbidity and mortality associated with SSc, there are no approved disease-modifying agents. Our objective in this study was to explore transcriptomic and model-based drug discovery approaches for SSc.<h4>Methods</h4>In this study, we explored the molecular basis for SSc pathogenesis in a well-studied mouse model of scleroderma. We profiled the skin and lung transcriptomes of mice at multiple timepoints, analysing the differential gene expression that underscores the development and resolution of bleomycin-induced fibrosis.<h4>Results</h4>We observed shared expression signatures of upregulati"],"journal":["Rheumatology (Oxford, England)"],"pagination":["1717-1727"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8996787"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptome analysis reveals key genes modulated by ALK5 inhibition in a bleomycin model of systemic sclerosis."],"pmcid":["PMC8996787"],"pubmed_authors":["Decato BE","Thompson JR","Azzara AV","Ammar R","Reinke-Breen L"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome analysis reveals key genes modulated by ALK5 inhibition in a bleomycin model of systemic sclerosis.","description":"<h4>Objective</h4>SSc is a rheumatic autoimmune disease affecting roughly 20 000 people worldwide and characterized by excessive collagen accumulation in the skin and internal organs. Despite the high morbidity and mortality associated with SSc, there are no approved disease-modifying agents. Our objective in this study was to explore transcriptomic and model-based drug discovery approaches for SSc.<h4>Methods</h4>In this study, we explored the molecular basis for SSc pathogenesis in a well-studied mouse model of scleroderma. We profiled the skin and lung transcriptomes of mice at multiple timepoints, analysing the differential gene expression that underscores the development and resolution of bleomycin-induced fibrosis.<h4>Results</h4>We observed shared expression signatures of upregulati","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-20T03:20:43.708Z","creation":"2025-04-06T02:52:18.666Z"},"accession":"S-EPMC8996787","cross_references":{"pubmed":["34289031"],"doi":["10.1093/rheumatology/keab580"]}}