{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["71(1)"],"submitter":["Lazurova Z"],"pubmed_abstract":["The endothelin system may play a role in the pathogenesis of vasovagal syncope (VVS) because it is implicated in blood pressure regulation. We hypothesized that endothelin-related genetic polymorphisms might modulate susceptibility to VVS. This study aimed to evaluate the possible influence of endothelin-1 (EDN1) and endothelin receptor A (EDNRA) gene variants on the occurrence of tilt-induced VVS and autonomic nervous system activity during the head-up tilt test (HUT). Results were expressed as mean +/- SEM. In 254 patients with recurrent syncope (age 45.33+/-1.22 years, 94 males, 160 females), heart rate variability (HRV) was measured during HUT. EDN1 rs5370 G>T and EDNRA rs5333 T>C gene polymorphisms were assessed using high-resolution melting analysis. There was no statistically signif"],"journal":["Physiological research"],"pagination":["93-101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8997676"],"repository":["biostudies-literature"],"pubmed_title":["Association of polymorphisms in endothelin-1 and endothelin receptor a genes with vasovagal syncope."],"pmcid":["PMC8997676"],"pubmed_authors":["Mitro P","Habalova V","Lazurova Z"],"additional_accession":[]},"is_claimable":false,"name":"Association of polymorphisms in endothelin-1 and endothelin receptor a genes with vasovagal syncope.","description":"The endothelin system may play a role in the pathogenesis of vasovagal syncope (VVS) because it is implicated in blood pressure regulation. We hypothesized that endothelin-related genetic polymorphisms might modulate susceptibility to VVS. This study aimed to evaluate the possible influence of endothelin-1 (EDN1) and endothelin receptor A (EDNRA) gene variants on the occurrence of tilt-induced VVS and autonomic nervous system activity during the head-up tilt test (HUT). Results were expressed as mean +/- SEM. In 254 patients with recurrent syncope (age 45.33+/-1.22 years, 94 males, 160 females), heart rate variability (HRV) was measured during HUT. EDN1 rs5370 G>T and EDNRA rs5333 T>C gene polymorphisms were assessed using high-resolution melting analysis. There was no statistically signif","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T10:49:25.379Z","creation":"2024-11-20T14:32:55.272Z"},"accession":"S-EPMC8997676","cross_references":{"pubmed":["35043642"],"doi":["10.33549/physiolres.934689"]}}