biostudies-literatureUnknown19(7)Aparisi ABackground (1): Headache is a prevalent symptom experienced during ongoing SARS-CoV-2 infection, but also weeks after recovery. Whether cardio-pulmonary dysfunction contributes causally to headache persistence is unknown. Methods (2): We conducted a case-control analysis nested in a prospective cohort study. Individuals were recruited from August 2020 to December 2020. Patients were grouped according to the presence or absence of long-COVID headache for three months after COVID-19 resolution. We compared demographic data, clinical variables, cardio-pulmonary laboratory biomarkers, quality of life, and cardio-pulmonary function between groups. Results (3): A cohort of 70 COVID-19 patients was evaluated. Patients with headaches (n = 10; 14.3%) were more frequently female (100% vs. 58.4%; <i>International journal of environmental research and public health3961https://www.ebi.ac.uk/biostudies/studies/S-EPMC8997887biostudies-literatureCardio-Pulmonary Dysfunction Evaluation in Patients with Persistent Post-COVID-19 Headache.PMC8997887Iglesias-Echeverria CGarcia-Azorin DAparisi AGarcia-Gomez MMarcos-Mangas MFernandez-de-Las-Penas CCarrasco-Moraleja MYbarra-Falcon CValle-Penacoba GGuerrero ALfalseCardio-Pulmonary Dysfunction Evaluation in Patients with Persistent Post-COVID-19 Headache.Background (1): Headache is a prevalent symptom experienced during ongoing SARS-CoV-2 infection, but also weeks after recovery. Whether cardio-pulmonary dysfunction contributes causally to headache persistence is unknown. Methods (2): We conducted a case-control analysis nested in a prospective cohort study. Individuals were recruited from August 2020 to December 2020. Patients were grouped according to the presence or absence of long-COVID headache for three months after COVID-19 resolution. We compared demographic data, clinical variables, cardio-pulmonary laboratory biomarkers, quality of life, and cardio-pulmonary function between groups. Results (3): A cohort of 70 COVID-19 patients was evaluated. Patients with headaches (n = 10; 14.3%) were more frequently female (100% vs. 58.4%; <i>2022-01-01T00:00:00Z2022 Mar2025-04-26T13:05:22.525Z2025-04-06T14:09:35.663ZS-EPMC89978873540964410.3390/ijerph19073961