biostudies-literatureXiao HGuangdong Basic and Applied Basic Research Foundation2700000https://www.ebi.ac.uk/biostudies/studies/S-EPMC9001072biostudies-literatureUnknown2022More and more attention has been paid to the use of traditional phytochemicals. Here, we first verified the therapeutic potential of a natural bioactive compound called Hinokitiol in myocardial ischemia reperfusion injury. Hinokitiol exerts cardioprotective effect through inhibition of GSK-3<i>β</i> and subsequent elimination of excessive autophagy, tuning autophagic activity in moderate extent for remedial profit in acute myocardial infarction and myocardial ischemia reperfusion injury. Overall, our study establishes Hinokitiol as a novel available interventional treatment for myocardial ischemia reperfusion injury.Oxidative medicine and cellular longevityHinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3<i>β</i>-Mediated Autophagy.PMC90010722018A030313980Liang SCai QLiu JYang ZXiao HChen XJin LfalseHinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3<i>β</i>-Mediated Autophagy.More and more attention has been paid to the use of traditional phytochemicals. Here, we first verified the therapeutic potential of a natural bioactive compound called Hinokitiol in myocardial ischemia reperfusion injury. Hinokitiol exerts cardioprotective effect through inhibition of GSK-3<i>β</i> and subsequent elimination of excessive autophagy, tuning autophagic activity in moderate extent for remedial profit in acute myocardial infarction and myocardial ischemia reperfusion injury. Overall, our study establishes Hinokitiol as a novel available interventional treatment for myocardial ischemia reperfusion injury.2022-01-01T00:00:00Z20222025-04-20T00:17:16.023Z2025-02-19T01:53:31.607ZS-EPMC90010723541916510.1155/2022/2700000