{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Su Z"],"funding":["National Natural Science Foundation of China","Sanming Project of Medicine in Shenzhen"],"pagination":["853529"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9001885"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["<b>Objective:</b> It aimed to construct the miRNA-mRNA regulatory network related to ion channel genes in mesial temporal lobe epilepsy (mTLE), and further identify the vital node in the network. <b>Methods:</b> Firstly, we identified ion channel-related differentially expressed genes (DEGs) in mTLE using the IUPHAR/BPS Guide to Pharmacology (GTP) database, neXtProt database, GeneCards database, and the high-throughput sequencing dataset. Then the STRING online database was used to construct a protein-protein interaction (PPI) network of DEGs, and the hub module in the PPI network was identified using the cytoHubba plug-in of Cytoscape software. In addition, the Single Cell Portal database was used to distinguish genes expression in different cell types. Based on the TarBase database, Epim"],"journal":["Frontiers in genetics"],"pubmed_title":["Identification of Ion Channel-Related Genes and miRNA-mRNA Networks in Mesial Temporal Lobe Epilepsy."],"pmcid":["PMC9001885"],"funding_grant_id":["82071447 81571266 81771405"],"pubmed_authors":["Liu X","Peng Y","Zhou L","Li Y","Su Z","Chen S","Zhao K"],"additional_accession":[]},"is_claimable":false,"name":"Identification of Ion Channel-Related Genes and miRNA-mRNA Networks in Mesial Temporal Lobe Epilepsy.","description":"<b>Objective:</b> It aimed to construct the miRNA-mRNA regulatory network related to ion channel genes in mesial temporal lobe epilepsy (mTLE), and further identify the vital node in the network. <b>Methods:</b> Firstly, we identified ion channel-related differentially expressed genes (DEGs) in mTLE using the IUPHAR/BPS Guide to Pharmacology (GTP) database, neXtProt database, GeneCards database, and the high-throughput sequencing dataset. Then the STRING online database was used to construct a protein-protein interaction (PPI) network of DEGs, and the hub module in the PPI network was identified using the cytoHubba plug-in of Cytoscape software. In addition, the Single Cell Portal database was used to distinguish genes expression in different cell types. Based on the TarBase database, Epim","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-20T03:19:46.771Z","creation":"2025-04-06T02:55:00.724Z"},"accession":"S-EPMC9001885","cross_references":{"pubmed":["35422840"],"doi":["10.3389/fgene.2022.853529"]}}