biostudies-literatureUnknown10Yi WMicrobial bactericides have been a research hotspot in recent years. In order to find new microbial fungicides for preventing and treating rice bacterial diseases, <i>Paenibacillus polymyxa</i> Y-1 (<i>P. polymyxa</i> Y-1) was isolated from <i>Dendrobium nobile</i> in this study, and the optimal medium was selected by a single-factor experiment, and then eight metabolites were isolated from <i>P. polymyxa</i> Y-1 fermentation broth by bioactivity tracking separation. The bioassay results showed that 2,4-di-tert-butylphenol, N-acetyl-5-methoxytryptamine, and P-hydroxybenzoic acid have good antibacterial activity against <i>Xanthomonas oryzae</i> pv. <i>Oryzicola</i> (<i>Xoo</i>) and <i>Xanthomonas oryzae</i> pv. <i>oryzae</i> (<i>Xoc</i>), with 50% effective concentration values of 49.45 μgFrontiers in chemistry879724https://www.ebi.ac.uk/biostudies/studies/S-EPMC9001896biostudies-literatureActive Metabolites From the Endophyte <i>Paenibacillus polymyxa</i> Y-1 of <i>Dendrobium nobile</i> for the Control of Rice Bacterial Diseases.PMC9001896Gan XChen CYi WfalseActive Metabolites From the Endophyte <i>Paenibacillus polymyxa</i> Y-1 of <i>Dendrobium nobile</i> for the Control of Rice Bacterial Diseases.Microbial bactericides have been a research hotspot in recent years. In order to find new microbial fungicides for preventing and treating rice bacterial diseases, <i>Paenibacillus polymyxa</i> Y-1 (<i>P. polymyxa</i> Y-1) was isolated from <i>Dendrobium nobile</i> in this study, and the optimal medium was selected by a single-factor experiment, and then eight metabolites were isolated from <i>P. polymyxa</i> Y-1 fermentation broth by bioactivity tracking separation. The bioassay results showed that 2,4-di-tert-butylphenol, N-acetyl-5-methoxytryptamine, and P-hydroxybenzoic acid have good antibacterial activity against <i>Xanthomonas oryzae</i> pv. <i>Oryzicola</i> (<i>Xoo</i>) and <i>Xanthomonas oryzae</i> pv. <i>oryzae</i> (<i>Xoc</i>), with 50% effective concentration values of 49.45 μg2022-01-01T00:00:00Z20222025-04-19T22:12:40.618Z2025-04-19T22:12:40.618ZS-EPMC90018963542576110.3389/fchem.2022.879724