{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bastia L"],"funding":["Canadian Institutes of Health Research","CIHR"],"pagination":["35"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9003155"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["<h4>Background</h4>External chest-wall compression (ECC) is sometimes used in ARDS patients despite lack of evidence. It is currently unknown whether this practice has any clinical benefit in patients with COVID-19 ARDS (C-ARDS) characterized by a respiratory system compliance (C<sub>rs</sub>) < 35 mL/cmH<sub>2</sub>O.<h4>Objectives</h4>To test if an ECC with a 5 L-bag in low-compliance C-ARDS can lead to a reduction in driving pressure (DP) and improve gas exchange, and to understand the underlying mechanisms.<h4>Methods</h4>Eleven patients with low-compliance C-ARDS were enrolled and underwent 4 steps: baseline, ECC for 60 min, ECC discontinuation and PEEP reduction. Respiratory mechanics, gas exchange, hemodynamics and electrical impedance tomography were recorded. Four pigs with acute "],"journal":["Annals of intensive care"],"pubmed_title":["External chest-wall compression in prolonged COVID-19 ARDS with low-compliance: a physiological study."],"pmcid":["PMC9003155"],"funding_grant_id":["PJT152898","PJT156336"],"pubmed_authors":["Forlini C","Brochard LJ","Fumagalli R","Engelberts D","Langer T","Spina S","Marrazzo F","Bellani G","Post M","Bassi G","Giudici R","Rezoagli E","Guarnieri M","Bastia L"],"additional_accession":[]},"is_claimable":false,"name":"External chest-wall compression in prolonged COVID-19 ARDS with low-compliance: a physiological study.","description":"<h4>Background</h4>External chest-wall compression (ECC) is sometimes used in ARDS patients despite lack of evidence. It is currently unknown whether this practice has any clinical benefit in patients with COVID-19 ARDS (C-ARDS) characterized by a respiratory system compliance (C<sub>rs</sub>) < 35 mL/cmH<sub>2</sub>O.<h4>Objectives</h4>To test if an ECC with a 5 L-bag in low-compliance C-ARDS can lead to a reduction in driving pressure (DP) and improve gas exchange, and to understand the underlying mechanisms.<h4>Methods</h4>Eleven patients with low-compliance C-ARDS were enrolled and underwent 4 steps: baseline, ECC for 60 min, ECC discontinuation and PEEP reduction. Respiratory mechanics, gas exchange, hemodynamics and electrical impedance tomography were recorded. Four pigs with acute ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-07-14T14:43:45.462Z","creation":"2026-06-20T03:11:15.363Z"},"accession":"S-EPMC9003155","cross_references":{"pubmed":["35412161"],"doi":["10.1186/s13613-022-01008-6"]}}