{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Marino A"],"funding":["Ministero della Salute","Japan Society for the Promotion of Science"],"pagination":["7678-89"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9003232"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(7)"],"pubmed_abstract":["Tetragonal barium titanate nanoparticles (BTNPs) have been exploited as nanotransducers owing to their piezoelectric properties, in order to provide indirect electrical stimulation to SH-SY5Y neuron-like cells. Following application of ultrasounds to cells treated with BTNPs, fluorescence imaging of ion dynamics revealed that the synergic stimulation is able to elicit a significant cellular response in terms of calcium and sodium fluxes; moreover, tests with appropriate blockers demonstrated that voltage-gated membrane channels are activated. The hypothesis of piezoelectric stimulation of neuron-like cells was supported by lack of cellular response in the presence of cubic nonpiezoelectric BTNPs, and further corroborated by a simple electroelastic model of a BTNP subjected to ultrasounds, according to which the generated voltage is compatible with the values required for the activation of voltage-sensitive channels."],"journal":["ACS nano"],"pubmed_title":["Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation."],"pmcid":["PMC9003232"],"funding_grant_id":["RF-2011-02350464","23687021"],"pubmed_authors":["Arai S","Sinibaldi E","Suzuki M","Mattoli V","Ciofani G","Marino A","Pellegrino M","Chang YT","Hou Y","Mazzolai B"],"additional_accession":[]},"is_claimable":false,"name":"Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation.","description":"Tetragonal barium titanate nanoparticles (BTNPs) have been exploited as nanotransducers owing to their piezoelectric properties, in order to provide indirect electrical stimulation to SH-SY5Y neuron-like cells. Following application of ultrasounds to cells treated with BTNPs, fluorescence imaging of ion dynamics revealed that the synergic stimulation is able to elicit a significant cellular response in terms of calcium and sodium fluxes; moreover, tests with appropriate blockers demonstrated that voltage-gated membrane channels are activated. The hypothesis of piezoelectric stimulation of neuron-like cells was supported by lack of cellular response in the presence of cubic nonpiezoelectric BTNPs, and further corroborated by a simple electroelastic model of a BTNP subjected to ultrasounds, according to which the generated voltage is compatible with the values required for the activation of voltage-sensitive channels.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2025-04-21T17:32:36.26Z","creation":"2025-04-05T16:40:36.088Z"},"accession":"S-EPMC9003232","cross_references":{"pubmed":["26168074"],"doi":["10.1021/acsnano.5b03162"]}}