biostudies-literatureSchmitt MMIntramural NIH HHSe131https://www.ebi.ac.uk/biostudies/studies/S-EPMC9004485biostudies-literatureUnknown2(4)<h4>Introduction</h4>Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a prototypic monogenic autoimmune disorder caused by AIRE deficiency-mediated impaired central immune tolerance. Although multiple endocrine and non-endocrine tissues are affected in APECED, the colon is an uncommon target of autoimmune attack. Mycophenolate is a potent immunomodulatory medication that is used to treat autoimmune manifestations in patients with APECED and other autoimmune diseases.<h4>Methods</h4>We reviewed the clinical, laboratory, genetic, histological, and treatment data of mycophenolate-induced colitis in our cohort of 104 APECED patients.<h4>Discussion</h4>Among 10 mycophenolate-treated APECED patients, four (40%) developed reversible biopsy-proven mycophenolate-induced coJPGN reportsMycophenolate-Induced Colitis in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients.PMC9004485ZIA AI001175Schmitt MMQuezado MMFerre EMNLionakis MSHeller TDe Melo MSCooper MAfalseMycophenolate-Induced Colitis in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients.<h4>Introduction</h4>Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a prototypic monogenic autoimmune disorder caused by AIRE deficiency-mediated impaired central immune tolerance. Although multiple endocrine and non-endocrine tissues are affected in APECED, the colon is an uncommon target of autoimmune attack. Mycophenolate is a potent immunomodulatory medication that is used to treat autoimmune manifestations in patients with APECED and other autoimmune diseases.<h4>Methods</h4>We reviewed the clinical, laboratory, genetic, histological, and treatment data of mycophenolate-induced colitis in our cohort of 104 APECED patients.<h4>Discussion</h4>Among 10 mycophenolate-treated APECED patients, four (40%) developed reversible biopsy-proven mycophenolate-induced co2021-01-01T00:00:00Z2021 Nov2025-04-04T22:32:26.763Z2025-02-19T03:23:46.893ZS-EPMC90044853542594410.1097/pg9.0000000000000131