{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(6)"],"submitter":["Maldonado M"],"pubmed_abstract":["The beneficial effects of caloric restriction (CR) against cardiac aging and for prevention of cardiovascular diseases are numerous. However, to our knowledge, there is no scientific evidence about how a high-calorie diet (HCD) background influences the mechanisms underlying CR in whole heart tissue (WHT) in experimental murine models. In the current study, CR-treated mice with different alimentary backgrounds were subjected to transthoracic echocardiographic measurements. WHT was then analyzed to determine cardiac energetics, telomerase activity, the expression of energy-sensing networks, tissue-specific adiponectin, and cardiac precursor/cardiac stem cell markers. Animals with a balanced diet consumption before CR presented marked cardiac remodeling with improved ejection fraction (EF) a"],"journal":["Aging"],"pagination":["2695-2719"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9004582"],"repository":["biostudies-literature"],"pubmed_title":["Effects of caloric overload before caloric restriction in the murine heart."],"pmcid":["PMC9004582"],"pubmed_authors":["Huang T","Yang L","Chen J","Zhou S","Jiang G","Raja MA","Zhong Y","Maldonado M","Duan H"],"additional_accession":[]},"is_claimable":false,"name":"Effects of caloric overload before caloric restriction in the murine heart.","description":"The beneficial effects of caloric restriction (CR) against cardiac aging and for prevention of cardiovascular diseases are numerous. However, to our knowledge, there is no scientific evidence about how a high-calorie diet (HCD) background influences the mechanisms underlying CR in whole heart tissue (WHT) in experimental murine models. In the current study, CR-treated mice with different alimentary backgrounds were subjected to transthoracic echocardiographic measurements. WHT was then analyzed to determine cardiac energetics, telomerase activity, the expression of energy-sensing networks, tissue-specific adiponectin, and cardiac precursor/cardiac stem cell markers. Animals with a balanced diet consumption before CR presented marked cardiac remodeling with improved ejection fraction (EF) a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-06-18T05:05:09.363Z","creation":"2025-04-04T23:16:07.23Z"},"accession":"S-EPMC9004582","cross_references":{"pubmed":["35347086"],"doi":["10.18632/aging.203967"]}}