biostudies-literatureUnknown14(6)Maldonado MThe beneficial effects of caloric restriction (CR) against cardiac aging and for prevention of cardiovascular diseases are numerous. However, to our knowledge, there is no scientific evidence about how a high-calorie diet (HCD) background influences the mechanisms underlying CR in whole heart tissue (WHT) in experimental murine models. In the current study, CR-treated mice with different alimentary backgrounds were subjected to transthoracic echocardiographic measurements. WHT was then analyzed to determine cardiac energetics, telomerase activity, the expression of energy-sensing networks, tissue-specific adiponectin, and cardiac precursor/cardiac stem cell markers. Animals with a balanced diet consumption before CR presented marked cardiac remodeling with improved ejection fraction (EF) aAging2695-2719https://www.ebi.ac.uk/biostudies/studies/S-EPMC9004582biostudies-literatureEffects of caloric overload before caloric restriction in the murine heart.PMC9004582Huang TYang LChen JZhou SJiang GRaja MAZhong YMaldonado MDuan HfalseEffects of caloric overload before caloric restriction in the murine heart.The beneficial effects of caloric restriction (CR) against cardiac aging and for prevention of cardiovascular diseases are numerous. However, to our knowledge, there is no scientific evidence about how a high-calorie diet (HCD) background influences the mechanisms underlying CR in whole heart tissue (WHT) in experimental murine models. In the current study, CR-treated mice with different alimentary backgrounds were subjected to transthoracic echocardiographic measurements. WHT was then analyzed to determine cardiac energetics, telomerase activity, the expression of energy-sensing networks, tissue-specific adiponectin, and cardiac precursor/cardiac stem cell markers. Animals with a balanced diet consumption before CR presented marked cardiac remodeling with improved ejection fraction (EF) a2022-01-01T00:00:00Z2022 Mar2026-06-18T05:05:09.363Z2025-04-04T23:16:07.23ZS-EPMC90045823534708610.18632/aging.203967