{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Christian JI"],"pubmed_abstract":["Tumors are composed of the tumor cells and the surrounding microenvironment. Both are closely interwoven and interact by a complex and multifaceted cross-talk which plays an integral part in tumor initiation, growth, and progression. <i>Dro1/Ccdc80</i> has been shown to be a potent suppressor of colorectal cancer and ubiquitous inactivation of <i>Dro1/Ccdc80</i> strongly promoted colorectal carcinogenesis in <i>Apc<sup>Min/+</sup></i> mice and in a chemically-induced colorectal cancer model. The aim of the present study was to investigate whether <i>Dro1/Ccdc80</i>'s tumor suppressive function is tumor-cell-autonomous. Expression of <i>Dro1/Ccdc80</i> in cancer cells had no effect on both colon tumor development in <i>Apc<sup>Min/+</sup></i> mice and formation of xenograft tumors. In contr"],"journal":["Oncotarget"],"pagination":["615-627"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9004603"],"repository":["biostudies-literature"],"pubmed_title":["Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis."],"pmcid":["PMC9004603"],"pubmed_authors":["Kolligs FT","Herbst A","Zierahn H","Wolf E","Neumann J","Marschall MK","Schneider MR","Christian JI","Ofner A","Quante M","Pastula A"],"additional_accession":[]},"is_claimable":false,"name":"Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis.","description":"Tumors are composed of the tumor cells and the surrounding microenvironment. Both are closely interwoven and interact by a complex and multifaceted cross-talk which plays an integral part in tumor initiation, growth, and progression. <i>Dro1/Ccdc80</i> has been shown to be a potent suppressor of colorectal cancer and ubiquitous inactivation of <i>Dro1/Ccdc80</i> strongly promoted colorectal carcinogenesis in <i>Apc<sup>Min/+</sup></i> mice and in a chemically-induced colorectal cancer model. The aim of the present study was to investigate whether <i>Dro1/Ccdc80</i>'s tumor suppressive function is tumor-cell-autonomous. Expression of <i>Dro1/Ccdc80</i> in cancer cells had no effect on both colon tumor development in <i>Apc<sup>Min/+</sup></i> mice and formation of xenograft tumors. In contr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T23:16:41.387Z","creation":"2025-04-04T23:16:41.387Z"},"accession":"S-EPMC9004603","cross_references":{"pubmed":["35422964"],"doi":["10.18632/oncotarget.28084"]}}