biostudies-literatureUnknown13Christian JITumors are composed of the tumor cells and the surrounding microenvironment. Both are closely interwoven and interact by a complex and multifaceted cross-talk which plays an integral part in tumor initiation, growth, and progression. Dro1/Ccdc80 has been shown to be a potent suppressor of colorectal cancer and ubiquitous inactivation of Dro1/Ccdc80 strongly promoted colorectal carcinogenesis in ApcMin/+ mice and in a chemically-induced colorectal cancer model. The aim of the present study was to investigate whether Dro1/Ccdc80's tumor suppressive function is tumor-cell-autonomous. Expression of Dro1/Ccdc80 in cancer cells had no effect on both colon tumor development in ApcMin/+ mice and formation of xenograft tumors. In contrOncotarget615-627https://www.ebi.ac.uk/biostudies/studies/S-EPMC9004603biostudies-literatureLoss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis.PMC9004603Kolligs FTHerbst AZierahn HWolf ENeumann JMarschall MKSchneider MRChristian JIOfner AQuante MPastula AfalseLoss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis.Tumors are composed of the tumor cells and the surrounding microenvironment. Both are closely interwoven and interact by a complex and multifaceted cross-talk which plays an integral part in tumor initiation, growth, and progression. Dro1/Ccdc80 has been shown to be a potent suppressor of colorectal cancer and ubiquitous inactivation of Dro1/Ccdc80 strongly promoted colorectal carcinogenesis in ApcMin/+ mice and in a chemically-induced colorectal cancer model. The aim of the present study was to investigate whether Dro1/Ccdc80's tumor suppressive function is tumor-cell-autonomous. Expression of Dro1/Ccdc80 in cancer cells had no effect on both colon tumor development in ApcMin/+ mice and formation of xenograft tumors. In contr2022-01-01T00:00:00Z20222025-04-04T23:16:41.387Z2025-04-04T23:16:41.387ZS-EPMC90046033542296410.18632/oncotarget.28084