{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(4)"],"submitter":["Pipolo C"],"pubmed_abstract":["The aim of the present study is to detect the presence of SARS-CoV-2 of patients affected by COVID-19 in olfactory mucosa (OM), sampled with nasal brushing (NB) and biopsy, and to assess whether a non-invasive procedure, such as NB, might be used as a large-scale procedure for demonstrating SARS-CoV-2 presence in olfactory neuroepithelium. Nasal brushings obtained from all the COVID-19 patients resulted positive to SARS-CoV-2 immunocytochemistry while controls were negative. Double immunofluorescence showed that SARS-CoV-2 positive cells included supporting cells as well as olfactory neurons and basal cells. OM biopsies showed an uneven distribution of SARS-CoV-2 positivity along the olfactory neuroepithelium, while OM from controls were negative. SARS-CoV-2 was distinctively found in sust"],"journal":["PloS one"],"pagination":["e0266740"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9004784"],"repository":["biostudies-literature"],"pubmed_title":["Evidence of SARS-CoV-2 in nasal brushings and olfactory mucosa biopsies of COVID-19 patients."],"pmcid":["PMC9004784"],"pubmed_authors":["Priori A","Pipolo C","Ferrari S","Spoldi C","Saibene AM","Felisati G","Fuccillo E","Muttini S","Castellani L","Bulfamante AM","Bulfamante GP","Martinelli C","Canevini MP","Zanusso G","Bruschi F","Aronica E","Bottai D","Chiumello D","Tosi D"],"additional_accession":[]},"is_claimable":false,"name":"Evidence of SARS-CoV-2 in nasal brushings and olfactory mucosa biopsies of COVID-19 patients.","description":"The aim of the present study is to detect the presence of SARS-CoV-2 of patients affected by COVID-19 in olfactory mucosa (OM), sampled with nasal brushing (NB) and biopsy, and to assess whether a non-invasive procedure, such as NB, might be used as a large-scale procedure for demonstrating SARS-CoV-2 presence in olfactory neuroepithelium. Nasal brushings obtained from all the COVID-19 patients resulted positive to SARS-CoV-2 immunocytochemistry while controls were negative. Double immunofluorescence showed that SARS-CoV-2 positive cells included supporting cells as well as olfactory neurons and basal cells. OM biopsies showed an uneven distribution of SARS-CoV-2 positivity along the olfactory neuroepithelium, while OM from controls were negative. SARS-CoV-2 was distinctively found in sust","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-21T17:33:52Z","creation":"2025-04-05T16:40:47.297Z"},"accession":"S-EPMC9004784","cross_references":{"pubmed":["35413071"],"doi":["10.1371/journal.pone.0266740"]}}