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A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI's magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance deviations from the additive model, we identify no genome-wide-significant SNPs, and a "],"journal":["Nature genetics"],"pubmed_title":["Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals."],"pmcid":["PMC9005349"],"funding_grant_id":["R01 AG015819","E42/15","2019-00244","ES/T014431/1","GNT113400","R01 AG034374","K99-AG062787-01","MR/S019669/1","P30 AG072975","R56 AG042568","R190-2014-3904","DE200100425","SDCC 3.A Complications","R01 AG042568","U01 MH109539","R24-AG065184","K99 AG062787","R24 AG065184","016.Veni.198.058","MC_UU_00007/10","R00 AG062787","P30 AG010161","FL180100072","R01-AG042568","P18-0782:18","R01 MH101244","R56-AG058726","421-2013-1061","R56 AG058726","OGI-152","R01 AG017917","647648"],"pubmed_authors":["Lebreton MP","Pickrell JK","Kaprio J","Kardia SLR","Martin NG","Uitterlinden AG","Sarin AP","Northover CAM","Okbay A","Verweij N","Miller 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million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI's magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance deviations from the additive model, we identify no genome-wide-significant SNPs, and a ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-03T10:21:23.174Z","creation":"2025-04-05T08:40:37.166Z"},"accession":"S-EPMC9005349","cross_references":{"pubmed":["35361970"],"doi":["10.1038/s41588-022-01016-z"]}}