biostudies-literatureUnknown8(1)Schnier C<h4>Introduction</h4>Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced incident dementia.<h4>Methods</h4>We analyzed the association of shingles vaccination with incident dementia in Wales between 2013 and 2020 using retrospectively collected national health data.<h4>Results</h4>Vaccinated individuals were at reduced risk of dementia (adjusted hazard ratio: 0.72; 95% confidence interval: 0.69 to 0.75). The association was not modified by a reduction in shingles diagnosis and was stronger for vascular dementia than for Alzheimer's disease. Vaccination was also associated with a reduction in several other diseases and all-cause mortality.<h4>Discussion</h4>Our study shows a clear association of shingles vaccination with reduced dementia, consistent with other observational cohort studies. The association may reflect selection bias with people choosing to be vaccinated having a higher healthy life expectancy.Alzheimer's & dementia (New York, N. Y.)e12293https://www.ebi.ac.uk/biostudies/studies/S-EPMC9006884biostudies-literatureReduced dementia incidence after varicella zoster vaccination in Wales 2013-2020.PMC9006884Haas JJanbek JSchnier CLathe RfalseReduced dementia incidence after varicella zoster vaccination in Wales 2013-2020.<h4>Introduction</h4>Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced incident dementia.<h4>Methods</h4>We analyzed the association of shingles vaccination with incident dementia in Wales between 2013 and 2020 using retrospectively collected national health data.<h4>Results</h4>Vaccinated individuals were at reduced risk of dementia (adjusted hazard ratio: 0.72; 95% confidence interval: 0.69 to 0.75). The association was not modified by a reduction in shingles diagnosis and was stronger for vascular dementia than for Alzheimer's disease. Vaccination was also associated with a reduction in several other diseases and all-cause mortality.<h4>Discussion</h4>Our study shows a clear association of shingles vaccination with reduced dementia, consistent with other observational cohort studies. The association may reflect selection bias with people choosing to be vaccinated having a higher healthy life expectancy.2022-01-01T00:00:00Z20222024-11-15T13:16:52.964Z2024-11-15T13:16:52.964ZS-EPMC90068843543425310.1002/trc2.12293