{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(4)"],"submitter":["Courlet P"],"funding":["World Anti-Doping Agency"],"pubmed_abstract":["Salbutamol was included in the prohibited list of the World Anti-Doping Agency (WADA) in 2004. Although systemic intake is banned, inhalation for asthma is permitted but with dosage restrictions. The WADA established a urinary concentration threshold to distinguish accordingly prohibited systemic self-administration from therapeutic prescription by inhalation. This study aimed at evaluating the ability of the WADA threshold to differentiate salbutamol therapeutic use from violation of antidoping rules. Concentration-time profile of salbutamol in plasma and its excretion in urine was characterized through a model-based meta-analysis of individual and aggregate data collected after administration of a large range of doses following different modes of administration and under a variety of con"],"journal":["CPT: pharmacometrics & systems pharmacology"],"pagination":["469-481"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9007606"],"repository":["biostudies-literature"],"pubmed_title":["Model-based meta-analysis of salbutamol pharmacokinetics and practical implications for doping control."],"pmcid":["PMC9007606"],"pubmed_authors":["Mazzoni I","Biollaz J","Guidi M","Courlet P","Buclin T","Rabin O"],"additional_accession":[]},"is_claimable":false,"name":"Model-based meta-analysis of salbutamol pharmacokinetics and practical implications for doping control.","description":"Salbutamol was included in the prohibited list of the World Anti-Doping Agency (WADA) in 2004. Although systemic intake is banned, inhalation for asthma is permitted but with dosage restrictions. The WADA established a urinary concentration threshold to distinguish accordingly prohibited systemic self-administration from therapeutic prescription by inhalation. This study aimed at evaluating the ability of the WADA threshold to differentiate salbutamol therapeutic use from violation of antidoping rules. Concentration-time profile of salbutamol in plasma and its excretion in urine was characterized through a model-based meta-analysis of individual and aggregate data collected after administration of a large range of doses following different modes of administration and under a variety of con","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-06-01T02:39:44.835Z","creation":"2025-06-01T02:39:44.835Z"},"accession":"S-EPMC9007606","cross_references":{"pubmed":["35315251"],"doi":["10.1002/psp4.12773"]}}