biostudies-literatureUnknown11(4)Courlet PWorld Anti-Doping AgencySalbutamol was included in the prohibited list of the World Anti-Doping Agency (WADA) in 2004. Although systemic intake is banned, inhalation for asthma is permitted but with dosage restrictions. The WADA established a urinary concentration threshold to distinguish accordingly prohibited systemic self-administration from therapeutic prescription by inhalation. This study aimed at evaluating the ability of the WADA threshold to differentiate salbutamol therapeutic use from violation of antidoping rules. Concentration-time profile of salbutamol in plasma and its excretion in urine was characterized through a model-based meta-analysis of individual and aggregate data collected after administration of a large range of doses following different modes of administration and under a variety of conCPT: pharmacometrics & systems pharmacology469-481https://www.ebi.ac.uk/biostudies/studies/S-EPMC9007606biostudies-literatureModel-based meta-analysis of salbutamol pharmacokinetics and practical implications for doping control.PMC9007606Mazzoni IBiollaz JGuidi MCourlet PBuclin TRabin OfalseModel-based meta-analysis of salbutamol pharmacokinetics and practical implications for doping control.Salbutamol was included in the prohibited list of the World Anti-Doping Agency (WADA) in 2004. Although systemic intake is banned, inhalation for asthma is permitted but with dosage restrictions. The WADA established a urinary concentration threshold to distinguish accordingly prohibited systemic self-administration from therapeutic prescription by inhalation. This study aimed at evaluating the ability of the WADA threshold to differentiate salbutamol therapeutic use from violation of antidoping rules. Concentration-time profile of salbutamol in plasma and its excretion in urine was characterized through a model-based meta-analysis of individual and aggregate data collected after administration of a large range of doses following different modes of administration and under a variety of con2022-01-01T00:00:00Z2022 Apr2025-06-01T02:39:44.835Z2025-06-01T02:39:44.835ZS-EPMC90076063531525110.1002/psp4.12773