biostudies-literatureGao ZNational Natural Science Foundation of China795240https://www.ebi.ac.uk/biostudies/studies/S-EPMC9008260biostudies-literatureUnknown13<h4>Background</h4>Previous studies have reported the effect of N⁷-methylguanosine (m⁷G) regulator methyltransferase like-1 protein (METTL1) in tumor initiation, metastasis, and chemosensitivity. However, the relationship between METTL1 and cancer immune infiltration is not validated and the prognostic significance of METTL1 in pan-cancer remains unclear.<h4>Methods</h4>Clinical parameters, including gender, age, lifetime, stage, and treatment response were analyzed to evaluate the prognostic significance of METTL1. To evaluate protein level of METTL1, the METTL1 activity was generated by single sample gene set enrichment analysis. The one-class logistic regression algorithm was used to calculate the stemness indices based on transcriptomics and methylation data of paFrontiers in immunologyA Comprehensive Analysis of METTL1 to Immunity and Stemness in Pan-Cancer.PMC900826081874083Li GFan YZhang ZZhao RGuo XWang SGao ZDeng LXu JXue HZhang PfalseA Comprehensive Analysis of METTL1 to Immunity and Stemness in Pan-Cancer.<h4>Background</h4>Previous studies have reported the effect of N⁷-methylguanosine (m⁷G) regulator methyltransferase like-1 protein (METTL1) in tumor initiation, metastasis, and chemosensitivity. However, the relationship between METTL1 and cancer immune infiltration is not validated and the prognostic significance of METTL1 in pan-cancer remains unclear.<h4>Methods</h4>Clinical parameters, including gender, age, lifetime, stage, and treatment response were analyzed to evaluate the prognostic significance of METTL1. To evaluate protein level of METTL1, the METTL1 activity was generated by single sample gene set enrichment analysis. The one-class logistic regression algorithm was used to calculate the stemness indices based on transcriptomics and methylation data of pa2022-01-01T00:00:00Z20222026-04-08T14:29:12.938Z2025-02-19T00:56:01.784ZS-EPMC90082603543233810.3389/fimmu.2022.795240