biostudies-literatureMaharaj ARNICHD NIH HHSNCATS NIH HHSNational Institute of Child Health and Human Development542-554https://www.ebi.ac.uk/biostudies/studies/S-EPMC9008710biostudies-literatureUnknown87(2)<h4>Aims</h4>The aim of this study was to evaluate the population pharmacokinetics (PopPK) of olanzapine in children and devise a model-informed paediatric dosing scheme.<h4>Methods</h4>The PopPK of olanzapine was characterized using opportunistically collected plasma samples from children receiving olanzapine per standard of care for any indication. A nonlinear mixed effect modelling approach was employed for model development using the software NONMEM (v7.4). Simulations from the developed PopPK model were used to devise a paediatric dosing scheme that targeted comparable plasma exposures to adolescents and adults.<h4>Results</h4>Forty-five participants contributed 83 plasma samples towards the analysis. The median (range) postnatal age and body weight of participants were 3.8 years (0.2British journal of clinical pharmacologyPopulation pharmacokinetics of olanzapine in children.PMC9008710HHSN267200700051CHHSN275201000003CK23 HD090239R01 HD097775HHSN275201000003IUL1 TR002369KL2 TR001115UL1 TR002538K23 HD091398Goldstein SLMaharaj ARCohen-Wolkowiez MWu HAl-Uzri ASherwin CMTPayne EHZimmerman KOKalra RWatt KErinjeri JHornik CPAutmizguine JfalsePopulation pharmacokinetics of olanzapine in children.<h4>Aims</h4>The aim of this study was to evaluate the population pharmacokinetics (PopPK) of olanzapine in children and devise a model-informed paediatric dosing scheme.<h4>Methods</h4>The PopPK of olanzapine was characterized using opportunistically collected plasma samples from children receiving olanzapine per standard of care for any indication. A nonlinear mixed effect modelling approach was employed for model development using the software NONMEM (v7.4). Simulations from the developed PopPK model were used to devise a paediatric dosing scheme that targeted comparable plasma exposures to adolescents and adults.<h4>Results</h4>Forty-five participants contributed 83 plasma samples towards the analysis. The median (range) postnatal age and body weight of participants were 3.8 years (0.22021-01-01T00:00:00Z2021 Feb2026-05-09T21:56:45.858Z2025-04-04T13:30:52.622ZS-EPMC90087103249730710.1111/bcp.14414