{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang JJ"],"funding":["Innovation Fund for Medical Sciences","Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program","Beijing Key Clinical Specialty for Laboratory Medicine-Excellent Project","National Natural Science Foundation of China","Chinese Academy of Medical Science"],"pagination":["1079-1089"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9009924"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["<i>Rhodotorula mucilaginosa</i>, an environmental yeast widely used in industry and agriculture, is also an opportunistic pathogen resistant to multi-antifungals. During the national surveillance in China, <i>R. mucilaginosa</i> has been documented from various hospitals and regions. At present, the molecular epidemiology of invasive infections caused by <i>R. mucilaginosa</i> and their resistance profiles to antifungals were unknown. Here we collected 49 strains from four hospitals located in different geographic regions from 2009 to 2019 in China, determined their genotypes using different molecular markers and quantified susceptibilities to various antifungals. Sequencing of ITS and D1/D2 regions in rDNA indicated that 73.5% (36/49) of clinical strains belong to same sequence type (rDNA"],"journal":["Emerging microbes & infections"],"pubmed_title":["Persistence of an epidemic cluster of <i>Rhodotorula mucilaginosa</i> in multiple geographic regions in China and the emergence of a 5-flucytosine resistant clone."],"pmcid":["PMC9009924"],"funding_grant_id":["81971979","ZK201000","32000024","2019-1002-02","20191080604"],"pubmed_authors":["Zhang G","Xu YC","Huang JJ","Cui LY","Fan X","Pang CJ","Shi Y","Xiao YL","Hu ZD","Xiao M","Tsui CKM","Wang WP","Chen XF","Gong J","Li YX"],"additional_accession":[]},"is_claimable":false,"name":"Persistence of an epidemic cluster of <i>Rhodotorula mucilaginosa</i> in multiple geographic regions in China and the emergence of a 5-flucytosine resistant clone.","description":"<i>Rhodotorula mucilaginosa</i>, an environmental yeast widely used in industry and agriculture, is also an opportunistic pathogen resistant to multi-antifungals. During the national surveillance in China, <i>R. mucilaginosa</i> has been documented from various hospitals and regions. At present, the molecular epidemiology of invasive infections caused by <i>R. mucilaginosa</i> and their resistance profiles to antifungals were unknown. Here we collected 49 strains from four hospitals located in different geographic regions from 2009 to 2019 in China, determined their genotypes using different molecular markers and quantified susceptibilities to various antifungals. Sequencing of ITS and D1/D2 regions in rDNA indicated that 73.5% (36/49) of clinical strains belong to same sequence type (rDNA","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-09T21:57:01.747Z","creation":"2024-11-12T10:08:11.074Z"},"accession":"S-EPMC9009924","cross_references":{"pubmed":["35343400"],"doi":["10.1080/22221751.2022.2059402"]}}