{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41(16)"],"submitter":["Zhang X"],"pubmed_abstract":["The tumor stroma of pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant and heterogeneous population of cancer-associated fibroblasts (CAFs), which are critically involved in chemoresistance. However, the underlying mechanism of CAFs in chemoresistance is unclear. Here, we show that CAF<sup>R</sup>, a CAF subset derived from platinum-resistant PDAC patients, assumes an iCAF phenotype and produces more IL8 than CAF<sup>S</sup> isolated from platinum-sensitive PDAC patients. CAF<sup>R</sup>-derived IL8 promotes oxaliplatin chemoresistance in PDAC. Based on long noncoding RNA (lncRNA) profiling in tumor cells incubated with CAF-CM, we found that UPK1A-AS1, whose expression is directly induced by IL8/NF-kappa B signaling, functions as a chemoresistance-promoting lncRNA and "],"journal":["Oncogene"],"pagination":["2372-2389"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9010302"],"repository":["biostudies-literature"],"pubmed_title":["Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair."],"pmcid":["PMC9010302"],"pubmed_authors":["Li G","Hu C","Lin Q","Li Z","Zhou Q","Zhang X","Zheng S","Lin H","Xia R","Ye Y","He R","Chen R"],"additional_accession":[]},"is_claimable":false,"name":"Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair.","description":"The tumor stroma of pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant and heterogeneous population of cancer-associated fibroblasts (CAFs), which are critically involved in chemoresistance. However, the underlying mechanism of CAFs in chemoresistance is unclear. Here, we show that CAF<sup>R</sup>, a CAF subset derived from platinum-resistant PDAC patients, assumes an iCAF phenotype and produces more IL8 than CAF<sup>S</sup> isolated from platinum-sensitive PDAC patients. CAF<sup>R</sup>-derived IL8 promotes oxaliplatin chemoresistance in PDAC. Based on long noncoding RNA (lncRNA) profiling in tumor cells incubated with CAF-CM, we found that UPK1A-AS1, whose expression is directly induced by IL8/NF-kappa B signaling, functions as a chemoresistance-promoting lncRNA and ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-05T09:38:40.132Z","creation":"2025-02-18T23:21:46.312Z"},"accession":"S-EPMC9010302","cross_references":{"pubmed":["35264742"],"doi":["10.1038/s41388-022-02253-6"]}}