{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(6)"],"submitter":["Lu F"],"pubmed_abstract":["<h4>Background</h4>Glioma is the most common intracranial primary malignancy, characterized by abnormal signal transductions caused by transcriptional and post-transcriptional regulators. Studies show the palmitoylation of oncoproteins and tumor suppressors participate in cancer progression, while studies of protein S-palmitoyltransferases in glioma are limited. A systematic analysis of zinc finger DHHC-type palmitoyltransferases (ZDHHC) in glioma is still lacking.<h4>Methods</h4>A prognostic heatmap and Kaplan-Meier overall survival plot of 24 members of the ZDHHC family in pan-cancer created. The expression and prognostic significance of ZDHHC12 was analyzed by using Gene Expression Profiling Interactive Analysis (GEPIA) and PrognoScan. DBTRG and U251 cells with silenced ZDHHC12 expressi"],"journal":["Annals of translational medicine"],"pagination":["334"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9011314"],"repository":["biostudies-literature"],"pubmed_title":["Hypomethylation-induced prognostic marker zinc finger DHHC-type palmitoyltransferase 12 contributes to glioblastoma progression."],"pmcid":["PMC9011314"],"pubmed_authors":["Liao J","Jiang X","Wu S","Shen SH","Wei","Lu F","Zheng P","Lin K","Zeng G"],"additional_accession":[]},"is_claimable":false,"name":"Hypomethylation-induced prognostic marker zinc finger DHHC-type palmitoyltransferase 12 contributes to glioblastoma progression.","description":"<h4>Background</h4>Glioma is the most common intracranial primary malignancy, characterized by abnormal signal transductions caused by transcriptional and post-transcriptional regulators. Studies show the palmitoylation of oncoproteins and tumor suppressors participate in cancer progression, while studies of protein S-palmitoyltransferases in glioma are limited. A systematic analysis of zinc finger DHHC-type palmitoyltransferases (ZDHHC) in glioma is still lacking.<h4>Methods</h4>A prognostic heatmap and Kaplan-Meier overall survival plot of 24 members of the ZDHHC family in pan-cancer created. The expression and prognostic significance of ZDHHC12 was analyzed by using Gene Expression Profiling Interactive Analysis (GEPIA) and PrognoScan. DBTRG and U251 cells with silenced ZDHHC12 expressi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-27T03:18:27.852Z","creation":"2025-04-06T18:47:10.095Z"},"accession":"S-EPMC9011314","cross_references":{"pubmed":["35434031"],"doi":["10.21037/atm-22-520"]}}