{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Li X"],"pubmed_abstract":["<h4>Objective</h4>To systematically assess the clinical efficacy of the <i>Jie Yu Wan</i> (JYW) formula in treating generalized anxiety disorder (GAD).<h4>Methods</h4>A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three patients with GAD were enrolled from 2017 to 2019. This study aimed to evaluate the effects of a Traditional Chinese Medicine (TCM) JYW formula on GAD at eight weeks, with the use of Buspirone as the comparator. A stepwise dosing protocol was used (JYW: high dose 24 g/day, low dose 12 g/day; Buspirone: high dose 30 mg/day, low dose 15 mg/day) and the dose was adjusted depending on whether the treatment response of Hamilton Anxiety Scale (HAMA) score was less th"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pagination":["9951693"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9012658"],"repository":["biostudies-literature"],"pubmed_title":["Effects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial."],"pmcid":["PMC9012658"],"pubmed_authors":["Ma R","Duan N","Chen J","Zhao A","Wei D","Zheng S","Jia H","Zhu H","Li X","Ding Y","Guo H","Jia Y","Feng S"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial.","description":"<h4>Objective</h4>To systematically assess the clinical efficacy of the <i>Jie Yu Wan</i> (JYW) formula in treating generalized anxiety disorder (GAD).<h4>Methods</h4>A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three patients with GAD were enrolled from 2017 to 2019. This study aimed to evaluate the effects of a Traditional Chinese Medicine (TCM) JYW formula on GAD at eight weeks, with the use of Buspirone as the comparator. A stepwise dosing protocol was used (JYW: high dose 24 g/day, low dose 12 g/day; Buspirone: high dose 30 mg/day, low dose 15 mg/day) and the dose was adjusted depending on whether the treatment response of Hamilton Anxiety Scale (HAMA) score was less th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T00:43:07.841Z","creation":"2025-04-07T11:44:45.254Z"},"accession":"S-EPMC9012658","cross_references":{"pubmed":["35432560"],"doi":["10.1155/2022/9951693"]}}