biostudies-literatureUnknown2022Li X<h4>Objective</h4>To systematically assess the clinical efficacy of the <i>Jie Yu Wan</i> (JYW) formula in treating generalized anxiety disorder (GAD).<h4>Methods</h4>A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three patients with GAD were enrolled from 2017 to 2019. This study aimed to evaluate the effects of a Traditional Chinese Medicine (TCM) JYW formula on GAD at eight weeks, with the use of Buspirone as the comparator. A stepwise dosing protocol was used (JYW: high dose 24 g/day, low dose 12 g/day; Buspirone: high dose 30 mg/day, low dose 15 mg/day) and the dose was adjusted depending on whether the treatment response of Hamilton Anxiety Scale (HAMA) score was less thEvidence-based complementary and alternative medicine : eCAM9951693https://www.ebi.ac.uk/biostudies/studies/S-EPMC9012658biostudies-literatureEffects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial.PMC9012658Ma RDuan NChen JZhao AWei DZheng SJia HZhu HLi XDing YGuo HJia YFeng SfalseEffects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial.<h4>Objective</h4>To systematically assess the clinical efficacy of the <i>Jie Yu Wan</i> (JYW) formula in treating generalized anxiety disorder (GAD).<h4>Methods</h4>A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three patients with GAD were enrolled from 2017 to 2019. This study aimed to evaluate the effects of a Traditional Chinese Medicine (TCM) JYW formula on GAD at eight weeks, with the use of Buspirone as the comparator. A stepwise dosing protocol was used (JYW: high dose 24 g/day, low dose 12 g/day; Buspirone: high dose 30 mg/day, low dose 15 mg/day) and the dose was adjusted depending on whether the treatment response of Hamilton Anxiety Scale (HAMA) score was less th2022-01-01T00:00:00Z20222025-04-19T00:43:07.841Z2025-04-07T11:44:45.254ZS-EPMC90126583543256010.1155/2022/9951693