{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Sasaki S"],"pubmed_abstract":["Renal type II sodium-dependent inorganic phosphate (Pi) transporters NaPi2a and NaPi2c cooperate with other organs to strictly regulate the plasma Pi concentration. A high Pi load induces expression and secretion of the phosphaturic hormones parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) that enhance urinary Pi excretion and prevent the onset of hyperphosphatemia. How FGF23 secretion from bone is increased by a high Pi load and the setpoint of the plasma Pi concentration, however, are unclear. Here, we investigated the role of Transmembrane protein 174 (Tmem174) and observed evidence for gene co-expression networks in NaPi2a and NaPi2c function. Tmem174 is localized in the renal proximal tubules and interacts with NaPi2a, but not NaPi2c. In Tmem174-knockout (KO) mice, th"],"journal":["Scientific reports"],"pagination":["6353"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9012787"],"repository":["biostudies-literature"],"pubmed_title":["Tmem174, a regulator of phosphate transporter prevents hyperphosphatemia."],"pmcid":["PMC9012787"],"pubmed_authors":["Uga M","Tanifuji K","Hasegawa T","Miyamoto KI","Sasaki S","Nagamori S","Kanai Y","Kawahara K","Kaneko I","Wiriyasermkul P","Segawa H","Hanazaki A","Koike M","Kawamoto Y","Amizuka N","Shiozaki Y"],"additional_accession":[]},"is_claimable":false,"name":"Tmem174, a regulator of phosphate transporter prevents hyperphosphatemia.","description":"Renal type II sodium-dependent inorganic phosphate (Pi) transporters NaPi2a and NaPi2c cooperate with other organs to strictly regulate the plasma Pi concentration. A high Pi load induces expression and secretion of the phosphaturic hormones parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) that enhance urinary Pi excretion and prevent the onset of hyperphosphatemia. How FGF23 secretion from bone is increased by a high Pi load and the setpoint of the plasma Pi concentration, however, are unclear. Here, we investigated the role of Transmembrane protein 174 (Tmem174) and observed evidence for gene co-expression networks in NaPi2a and NaPi2c function. Tmem174 is localized in the renal proximal tubules and interacts with NaPi2a, but not NaPi2c. In Tmem174-knockout (KO) mice, th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T19:42:25.08Z","creation":"2025-02-19T03:42:06.196Z"},"accession":"S-EPMC9012787","cross_references":{"pubmed":["35428804"],"doi":["10.1038/s41598-022-10409-3"]}}