{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li M"],"funding":["Natural Science Foundation of Zhejiang Province","National Natural Science Foundation of China"],"pagination":["6349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9012805"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["The development of 3D printing has recently attracted significant attention on constructing complex three-dimensional physiological microenvironments. However, it is very challenging to provide a bio-ink with cell-harmless and high mold accuracy during extrusion in 3D printing. To overcome this issue, a technique improving the shear-thinning performance of semi-IPN bio-ink, which is universally applicable to all alginate/gelatin-based materials, was developed. Semi-IPN bio-ink prepared by cyclic heating-cooling treatment in this study can reduce the cell damage without sacrificing the accuracy of the scaffolds for its excellent shear-thinning performance. A more than 15% increase in post-printing Cell viability verified the feasibility of the strategy. Moreover, the bio-ink with low molecu"],"journal":["Scientific reports"],"pubmed_title":["High-cytocompatible semi-IPN bio-ink with wide molecular weight distribution for extrusion 3D bioprinting."],"pmcid":["PMC9012805"],"funding_grant_id":["No. 61873078","LY21H170002"],"pubmed_authors":["Liu K","Yao D","Shi T","Wang H","Yue X","Li M"],"additional_accession":[]},"is_claimable":false,"name":"High-cytocompatible semi-IPN bio-ink with wide molecular weight distribution for extrusion 3D bioprinting.","description":"The development of 3D printing has recently attracted significant attention on constructing complex three-dimensional physiological microenvironments. However, it is very challenging to provide a bio-ink with cell-harmless and high mold accuracy during extrusion in 3D printing. To overcome this issue, a technique improving the shear-thinning performance of semi-IPN bio-ink, which is universally applicable to all alginate/gelatin-based materials, was developed. Semi-IPN bio-ink prepared by cyclic heating-cooling treatment in this study can reduce the cell damage without sacrificing the accuracy of the scaffolds for its excellent shear-thinning performance. A more than 15% increase in post-printing Cell viability verified the feasibility of the strategy. Moreover, the bio-ink with low molecu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T20:37:17.081Z","creation":"2025-02-19T03:41:56.931Z"},"accession":"S-EPMC9012805","cross_references":{"pubmed":["35428800"],"doi":["10.1038/s41598-022-10338-1"]}}