{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li M"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["206"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9013375"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Post-translational modifications (PTMs) are a covalent processing process of proteins after translation. Proteins are capable of playing their roles only after being modified, so as to maintain the normal physiological function of cells. As a key modification of protein post-translational modification, ubiquitination is an essential element, which forms an enzyme-linked reaction through ubiquitin-activating enzyme, ubiquitin binding enzyme, and ubiquitin ligase, aiming to regulate the expression level and function of cellular proteins. Nedd4 family is the largest group of ubiquitin ligases, including 9 members, such as Nedd4-1, Nedd4L (Nedd4-2), WWP1, WWP2, ITCH, etc. They could bind to substrate proteins through their WW domain and play a dominant role in the ubiquitination process, and t"],"journal":["Cell death discovery"],"pubmed_title":["Research progress of Nedd4L in cardiovascular diseases."],"pmcid":["PMC9013375"],"funding_grant_id":["81900355","82171572","81970211","81900372"],"pubmed_authors":["Cao K","Wang P","Zhang Y","Song C","Zhang N","Wang W","Sun G","Sun Y","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Research progress of Nedd4L in cardiovascular diseases.","description":"Post-translational modifications (PTMs) are a covalent processing process of proteins after translation. Proteins are capable of playing their roles only after being modified, so as to maintain the normal physiological function of cells. As a key modification of protein post-translational modification, ubiquitination is an essential element, which forms an enzyme-linked reaction through ubiquitin-activating enzyme, ubiquitin binding enzyme, and ubiquitin ligase, aiming to regulate the expression level and function of cellular proteins. Nedd4 family is the largest group of ubiquitin ligases, including 9 members, such as Nedd4-1, Nedd4L (Nedd4-2), WWP1, WWP2, ITCH, etc. They could bind to substrate proteins through their WW domain and play a dominant role in the ubiquitination process, and t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-31T12:58:40.306Z","creation":"2025-04-06T21:49:01.677Z"},"accession":"S-EPMC9013375","cross_references":{"pubmed":["35429991"],"doi":["10.1038/s41420-022-01017-1"]}}