biostudies-literatureLi MNational Natural Science Foundation of China (National Science Foundation of China)206https://www.ebi.ac.uk/biostudies/studies/S-EPMC9013375biostudies-literatureUnknown8(1)Post-translational modifications (PTMs) are a covalent processing process of proteins after translation. Proteins are capable of playing their roles only after being modified, so as to maintain the normal physiological function of cells. As a key modification of protein post-translational modification, ubiquitination is an essential element, which forms an enzyme-linked reaction through ubiquitin-activating enzyme, ubiquitin binding enzyme, and ubiquitin ligase, aiming to regulate the expression level and function of cellular proteins. Nedd4 family is the largest group of ubiquitin ligases, including 9 members, such as Nedd4-1, Nedd4L (Nedd4-2), WWP1, WWP2, ITCH, etc. They could bind to substrate proteins through their WW domain and play a dominant role in the ubiquitination process, and tCell death discoveryResearch progress of Nedd4L in cardiovascular diseases.PMC901337581900355821715728197021181900372Cao KWang PZhang YSong CZhang NWang WSun GSun YLi MfalseResearch progress of Nedd4L in cardiovascular diseases.Post-translational modifications (PTMs) are a covalent processing process of proteins after translation. Proteins are capable of playing their roles only after being modified, so as to maintain the normal physiological function of cells. As a key modification of protein post-translational modification, ubiquitination is an essential element, which forms an enzyme-linked reaction through ubiquitin-activating enzyme, ubiquitin binding enzyme, and ubiquitin ligase, aiming to regulate the expression level and function of cellular proteins. Nedd4 family is the largest group of ubiquitin ligases, including 9 members, such as Nedd4-1, Nedd4L (Nedd4-2), WWP1, WWP2, ITCH, etc. They could bind to substrate proteins through their WW domain and play a dominant role in the ubiquitination process, and t2022-01-01T00:00:00Z2022 Apr2026-05-31T12:58:40.306Z2025-04-06T21:49:01.677ZS-EPMC90133753542999110.1038/s41420-022-01017-1