biostudies-literatureHan JWMinistry of Science and ICTNational Research Foundation of Korea219-231https://www.ebi.ac.uk/biostudies/studies/S-EPMC9013623biostudies-literatureUnknown28(2)<h4>Background/aims</h4>Sarcopenia is an independent prognostic factor of liver cirrhosis (LC). However, the association between LC-related systemic inflammation and sarcopenia is unclear.<h4>Methods</h4>Sprague-Dawley rats were treated with thioacetamide (TAA) or saline as a control. Rifaximin was administered to TAA-induced LC rats. Enzyme-linked immunosorbent assay was performed to measure inflammatory mediators in rat serum. RT-PCR was performed to measure the molecular expression in tissues. Hematoxylin and eosin (H&E) staining and immunohistochemistry were performed to investigate tissue pathology. Serum tumor necrosis factor-α levels, liver stiffness (LS), and the L3 skeletal muscle index (L3SMI) were measured in 60 patients with chronic liver disease.<h4>Results</h4>LC and sarcopenClinical and molecular hepatologyAssociation between serum tumor necrosis factor-α and sarcopenia in liver cirrhosis.PMC90136232017R1C1B5076061Kim DINam HCChang UISong DSYang JMHan JWfalseAssociation between serum tumor necrosis factor-α and sarcopenia in liver cirrhosis.<h4>Background/aims</h4>Sarcopenia is an independent prognostic factor of liver cirrhosis (LC). However, the association between LC-related systemic inflammation and sarcopenia is unclear.<h4>Methods</h4>Sprague-Dawley rats were treated with thioacetamide (TAA) or saline as a control. Rifaximin was administered to TAA-induced LC rats. Enzyme-linked immunosorbent assay was performed to measure inflammatory mediators in rat serum. RT-PCR was performed to measure the molecular expression in tissues. Hematoxylin and eosin (H&E) staining and immunohistochemistry were performed to investigate tissue pathology. Serum tumor necrosis factor-α levels, liver stiffness (LS), and the L3 skeletal muscle index (L3SMI) were measured in 60 patients with chronic liver disease.<h4>Results</h4>LC and sarcopen2022-01-01T00:00:00Z2022 Apr2025-04-22T01:44:31.489Z2025-04-05T20:05:12.671ZS-EPMC90136233428129510.3350/cmh.2021.0082