{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Fateh ST"],"pubmed_abstract":["Cellular differentiation is pivotal in health and disease. Interfering with the process of differentiation, such as inhibiting the differentiation of adipocytes and inducing the differentiation of cancer cells, is considered a therapeutic approach. Sesquiterpene lactones, primarily found in plants, have been attracted attention as differentiating/dedifferentiating agents tested on various human or animal cells. However, a consensus on sesquiterpene lactones' effects and their mechanism of action is required. In this sense, through a systematic review, we have investigated the differentiating/dedifferentiating effects of sesquiterpene lactones on human or animal cells. 13 different cell lines originated from humans, mice, and rats, in addition to the effects of a total of 21 sesquiterpene l"],"journal":["Frontiers in pharmacology"],"pagination":["862446"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9014292"],"repository":["biostudies-literature"],"pubmed_title":["The Effects of Sesquiterpene Lactones on the Differentiation of Human or Animal Cells Cultured <i>In-Vitro</i>: A Critical Systematic Review."],"pmcid":["PMC9014292"],"pubmed_authors":["Shekari F","Mahdavi M","Aref AR","Fateh ST","Salehi-Najafabadi A"],"additional_accession":[]},"is_claimable":false,"name":"The Effects of Sesquiterpene Lactones on the Differentiation of Human or Animal Cells Cultured <i>In-Vitro</i>: A Critical Systematic Review.","description":"Cellular differentiation is pivotal in health and disease. Interfering with the process of differentiation, such as inhibiting the differentiation of adipocytes and inducing the differentiation of cancer cells, is considered a therapeutic approach. Sesquiterpene lactones, primarily found in plants, have been attracted attention as differentiating/dedifferentiating agents tested on various human or animal cells. However, a consensus on sesquiterpene lactones' effects and their mechanism of action is required. In this sense, through a systematic review, we have investigated the differentiating/dedifferentiating effects of sesquiterpene lactones on human or animal cells. 13 different cell lines originated from humans, mice, and rats, in addition to the effects of a total of 21 sesquiterpene l","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T23:00:03.529Z","creation":"2025-04-07T10:43:33.275Z"},"accession":"S-EPMC9014292","cross_references":{"pubmed":["35444549"],"doi":["10.3389/fphar.2022.862446"]}}