biostudies-literatureUnknown13Fateh STCellular differentiation is pivotal in health and disease. Interfering with the process of differentiation, such as inhibiting the differentiation of adipocytes and inducing the differentiation of cancer cells, is considered a therapeutic approach. Sesquiterpene lactones, primarily found in plants, have been attracted attention as differentiating/dedifferentiating agents tested on various human or animal cells. However, a consensus on sesquiterpene lactones' effects and their mechanism of action is required. In this sense, through a systematic review, we have investigated the differentiating/dedifferentiating effects of sesquiterpene lactones on human or animal cells. 13 different cell lines originated from humans, mice, and rats, in addition to the effects of a total of 21 sesquiterpene lFrontiers in pharmacology862446https://www.ebi.ac.uk/biostudies/studies/S-EPMC9014292biostudies-literatureThe Effects of Sesquiterpene Lactones on the Differentiation of Human or Animal Cells Cultured <i>In-Vitro</i>: A Critical Systematic Review.PMC9014292Shekari FMahdavi MAref ARFateh STSalehi-Najafabadi AfalseThe Effects of Sesquiterpene Lactones on the Differentiation of Human or Animal Cells Cultured <i>In-Vitro</i>: A Critical Systematic Review.Cellular differentiation is pivotal in health and disease. Interfering with the process of differentiation, such as inhibiting the differentiation of adipocytes and inducing the differentiation of cancer cells, is considered a therapeutic approach. Sesquiterpene lactones, primarily found in plants, have been attracted attention as differentiating/dedifferentiating agents tested on various human or animal cells. However, a consensus on sesquiterpene lactones' effects and their mechanism of action is required. In this sense, through a systematic review, we have investigated the differentiating/dedifferentiating effects of sesquiterpene lactones on human or animal cells. 13 different cell lines originated from humans, mice, and rats, in addition to the effects of a total of 21 sesquiterpene l2022-01-01T00:00:00Z20222025-04-18T23:00:03.529Z2025-04-07T10:43:33.275ZS-EPMC90142923544454910.3389/fphar.2022.862446