{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(4)"],"submitter":["Thanabalasingam SJ"],"pubmed_abstract":["<h4>Rationale & objective</h4>The Kidney Failure Risk Equation (KFRE) is widely used to predict the risk of kidney replacement therapy (KRT) initiation in chronic kidney disease (CKD) stages G3-G5. The new Grams calculator developed for advanced CKD (stage G4+) predicts KRT initiation, cardiovascular events, and death by uniquely incorporating the competing risk of death. We aimed to validate this tool in a stage G4+ cohort for death and KRT.<h4>Study design</h4>Retrospective cohort study.<h4>Setting & participants</h4>442 patients with CKD stage G4+ (mean ± SD age, 73 ± 12 years; mean ± SD estimated glomerular filtration rate, 20 ± 6.2 mL/min/1.73 m<sup>2</sup>) who visited the multidisciplinary CKD clinic at Kingston Health Sciences Center in Ontario, Canada.<h4>Outcomes & analytical app"],"journal":["Kidney medicine"],"pagination":["100440"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9014437"],"repository":["biostudies-literature"],"pubmed_title":["Independent External Validation and Comparison of Death and Kidney Replacement Therapy Prediction Models in Advanced CKD."],"pmcid":["PMC9014437"],"pubmed_authors":["Iliescu EA","Norman PA","Hundemer GL","Thanabalasingam SJ","White CA","Day AG","Akbari A"],"additional_accession":[]},"is_claimable":false,"name":"Independent External Validation and Comparison of Death and Kidney Replacement Therapy Prediction Models in Advanced CKD.","description":"<h4>Rationale & objective</h4>The Kidney Failure Risk Equation (KFRE) is widely used to predict the risk of kidney replacement therapy (KRT) initiation in chronic kidney disease (CKD) stages G3-G5. The new Grams calculator developed for advanced CKD (stage G4+) predicts KRT initiation, cardiovascular events, and death by uniquely incorporating the competing risk of death. We aimed to validate this tool in a stage G4+ cohort for death and KRT.<h4>Study design</h4>Retrospective cohort study.<h4>Setting & participants</h4>442 patients with CKD stage G4+ (mean ± SD age, 73 ± 12 years; mean ± SD estimated glomerular filtration rate, 20 ± 6.2 mL/min/1.73 m<sup>2</sup>) who visited the multidisciplinary CKD clinic at Kingston Health Sciences Center in Ontario, Canada.<h4>Outcomes & analytical app","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-18T23:01:34.087Z","creation":"2025-04-07T10:45:04.629Z"},"accession":"S-EPMC9014437","cross_references":{"pubmed":["35445190"],"doi":["10.1016/j.xkme.2022.100440"]}}