biostudies-literatureUnknown4(4)Thanabalasingam SJ<h4>Rationale & objective</h4>The Kidney Failure Risk Equation (KFRE) is widely used to predict the risk of kidney replacement therapy (KRT) initiation in chronic kidney disease (CKD) stages G3-G5. The new Grams calculator developed for advanced CKD (stage G4+) predicts KRT initiation, cardiovascular events, and death by uniquely incorporating the competing risk of death. We aimed to validate this tool in a stage G4+ cohort for death and KRT.<h4>Study design</h4>Retrospective cohort study.<h4>Setting & participants</h4>442 patients with CKD stage G4+ (mean ± SD age, 73 ± 12 years; mean ± SD estimated glomerular filtration rate, 20 ± 6.2 mL/min/1.73 m²) who visited the multidisciplinary CKD clinic at Kingston Health Sciences Center in Ontario, Canada.<h4>Outcomes & analytical appKidney medicine100440https://www.ebi.ac.uk/biostudies/studies/S-EPMC9014437biostudies-literatureIndependent External Validation and Comparison of Death and Kidney Replacement Therapy Prediction Models in Advanced CKD.PMC9014437Iliescu EANorman PAHundemer GLThanabalasingam SJWhite CADay AGAkbari AfalseIndependent External Validation and Comparison of Death and Kidney Replacement Therapy Prediction Models in Advanced CKD.<h4>Rationale & objective</h4>The Kidney Failure Risk Equation (KFRE) is widely used to predict the risk of kidney replacement therapy (KRT) initiation in chronic kidney disease (CKD) stages G3-G5. The new Grams calculator developed for advanced CKD (stage G4+) predicts KRT initiation, cardiovascular events, and death by uniquely incorporating the competing risk of death. We aimed to validate this tool in a stage G4+ cohort for death and KRT.<h4>Study design</h4>Retrospective cohort study.<h4>Setting & participants</h4>442 patients with CKD stage G4+ (mean ± SD age, 73 ± 12 years; mean ± SD estimated glomerular filtration rate, 20 ± 6.2 mL/min/1.73 m²) who visited the multidisciplinary CKD clinic at Kingston Health Sciences Center in Ontario, Canada.<h4>Outcomes & analytical app2022-01-01T00:00:00Z2022 Apr2025-04-18T23:01:34.087Z2025-04-07T10:45:04.629ZS-EPMC90144373544519010.1016/j.xkme.2022.100440