biostudies-literatureUnknown20(1)Colchero MA<h4>Background</h4>The Seguro Popular (SP) was launched in 2004 to increase access to healthcare and reduce catastrophic expenditures among the Mexican population. To document the evidence on its effectiveness, we conducted a systematic review of impact evaluations of the SP.<h4>Methods</h4>We included papers using rigorous quasi-experimental designs to assess the effectiveness of the SP. We evaluated the quality of each study and presented the statistical significance of the effects by outcome category.<h4>Results</h4>We identified 26 papers that met the inclusion criteria. Sixteen studies that evaluated the impact of SP on financial protection found consistent and statistically significant positive effects in 55% of the 65 outcomes analyzed. Nine studies evaluating utilization of health Health research policy and systems42https://www.ebi.ac.uk/biostudies/studies/S-EPMC9014564biostudies-literatureA systematic review of the literature on the impact of the Seguro Popular.PMC9014564Colchero MAGomez RBautista-Arredondo SfalseA systematic review of the literature on the impact of the Seguro Popular.<h4>Background</h4>The Seguro Popular (SP) was launched in 2004 to increase access to healthcare and reduce catastrophic expenditures among the Mexican population. To document the evidence on its effectiveness, we conducted a systematic review of impact evaluations of the SP.<h4>Methods</h4>We included papers using rigorous quasi-experimental designs to assess the effectiveness of the SP. We evaluated the quality of each study and presented the statistical significance of the effects by outcome category.<h4>Results</h4>We identified 26 papers that met the inclusion criteria. Sixteen studies that evaluated the impact of SP on financial protection found consistent and statistically significant positive effects in 55% of the 65 outcomes analyzed. Nine studies evaluating utilization of health 2022-01-01T00:00:00Z2022 Apr2026-03-17T15:51:15.27Z2025-04-05T15:07:01.76ZS-EPMC90145643543693810.1186/s12961-022-00839-w