{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ng YS"],"funding":["Biotechnology and Biological Sciences Research Council and Medical Research Council","UK National Institute for Health Research (NIHR) Biomedical Research Centre for Ageing and Age-Related Disease award to the Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust","Department of Health’s National Institute for Health Research Biomedical Research Centres funding scheme","UK Medical Research Council and Brains for Dementia Research, a joint venture between Alzheimer’s Society and Alzheimer’s Research UK","Alzheimer’s Research UK Fellowship","Medical Research Council Clinician Scientist Fellowship","Wellcome Centre for Mitochondrial Research","Lily Foundation","Medical Research Council Centre of Neuromuscular Diseases for his PhD study","NIHR Clinical Lectureship in Neurology","Medical Research Council","National Institute for Health Research (NIHR)","Alzheimer's Society","Medical Research Council strategic award to establish an International Centre for Genomic Medicine in Neuromuscular Diseases","Wellcome Trust"],"pagination":["542-554"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9014738"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145(2)"],"pubmed_abstract":["In this retrospective, multicentre, observational cohort study, we sought to determine the clinical, radiological, EEG, genetics and neuropathological characteristics of mitochondrial stroke-like episodes and to identify associated risk predictors. Between January 1998 and June 2018, we identified 111 patients with genetically determined mitochondrial disease who developed stroke-like episodes. Post-mortem cases of mitochondrial disease (n = 26) were identified from Newcastle Brain Tissue Resource. The primary outcome was to interrogate the clinico-radiopathological correlates and prognostic indicators of stroke-like episode in patients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS). The secondary objective was to develop a multivariable pre"],"journal":["Brain : a journal of neurology"],"pubmed_title":["Forecasting stroke-like episodes and outcomes in mitochondrial disease."],"pmcid":["PMC9014738"],"funding_grant_id":["CL-2016-01-003","MR/K000608/1","G0400074","L016354","G1100540","MR/S002065/1","ARUK-RF2018C-005","MR/S005021/1","181","G0502157","G0900652","203105"],"pubmed_authors":["Erskine D","McFarland R","Whittaker RG","Baird T","Chrysostomou A","Hanna MG","Murphy K","Hirst C","Blain AP","Morris CM","Farrugia ME","Pitceathly RDS","Feeney C","Hall J","Schaefer AM","Poulton J","Baker MR","Duncan C","Winder A","Nesbitt V","Gorman GS","Maddison P","Blakely EL","Taylor RW","Lax NZ","Roberts M","Turnbull DM","Ng YS","Polvikoski T","Thomas RH","Lai M","Gebbels A","Lawthom C"],"additional_accession":[]},"is_claimable":false,"name":"Forecasting stroke-like episodes and outcomes in mitochondrial disease.","description":"In this retrospective, multicentre, observational cohort study, we sought to determine the clinical, radiological, EEG, genetics and neuropathological characteristics of mitochondrial stroke-like episodes and to identify associated risk predictors. Between January 1998 and June 2018, we identified 111 patients with genetically determined mitochondrial disease who developed stroke-like episodes. Post-mortem cases of mitochondrial disease (n = 26) were identified from Newcastle Brain Tissue Resource. The primary outcome was to interrogate the clinico-radiopathological correlates and prognostic indicators of stroke-like episode in patients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS). The secondary objective was to develop a multivariable pre","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T19:42:32.653Z","creation":"2025-02-19T04:04:32.657Z"},"accession":"S-EPMC9014738","cross_references":{"pubmed":["34927673"],"doi":["10.1093/brain/awab353"]}}