biostudies-literatureNg YSBiotechnology and Biological Sciences Research Council and Medical Research CouncilUK National Institute for Health Research (NIHR) Biomedical Research Centre for Ageing and Age-Related Disease award to the Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation TrustDepartment of Health’s National Institute for Health Research Biomedical Research Centres funding schemeUK Medical Research Council and Brains for Dementia Research, a joint venture between Alzheimer’s Society and Alzheimer’s Research UKAlzheimer’s Research UK FellowshipMedical Research Council Clinician Scientist FellowshipWellcome Centre for Mitochondrial ResearchLily FoundationMedical Research Council Centre of Neuromuscular Diseases for his PhD studyNIHR Clinical Lectureship in NeurologyMedical Research CouncilNational Institute for Health Research (NIHR)Alzheimer's SocietyMedical Research Council strategic award to establish an International Centre for Genomic Medicine in Neuromuscular DiseasesWellcome Trust542-554https://www.ebi.ac.uk/biostudies/studies/S-EPMC9014738biostudies-literatureUnknown145(2)In this retrospective, multicentre, observational cohort study, we sought to determine the clinical, radiological, EEG, genetics and neuropathological characteristics of mitochondrial stroke-like episodes and to identify associated risk predictors. Between January 1998 and June 2018, we identified 111 patients with genetically determined mitochondrial disease who developed stroke-like episodes. Post-mortem cases of mitochondrial disease (n = 26) were identified from Newcastle Brain Tissue Resource. The primary outcome was to interrogate the clinico-radiopathological correlates and prognostic indicators of stroke-like episode in patients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS). The secondary objective was to develop a multivariable preBrain : a journal of neurologyForecasting stroke-like episodes and outcomes in mitochondrial disease.PMC9014738CL-2016-01-003MR/K000608/1G0400074L016354G1100540MR/S002065/1ARUK-RF2018C-005MR/S005021/1181G0502157G0900652203105Erskine DMcFarland RWhittaker RGBaird TChrysostomou AHanna MGMurphy KHirst CBlain APMorris CMFarrugia MEPitceathly RDSFeeney CHall JSchaefer AMPoulton JBaker MRDuncan CWinder ANesbitt VGorman GSMaddison PBlakely ELTaylor RWLax NZRoberts MTurnbull DMNg YSPolvikoski TThomas RHLai MGebbels ALawthom CfalseForecasting stroke-like episodes and outcomes in mitochondrial disease.In this retrospective, multicentre, observational cohort study, we sought to determine the clinical, radiological, EEG, genetics and neuropathological characteristics of mitochondrial stroke-like episodes and to identify associated risk predictors. Between January 1998 and June 2018, we identified 111 patients with genetically determined mitochondrial disease who developed stroke-like episodes. Post-mortem cases of mitochondrial disease (n = 26) were identified from Newcastle Brain Tissue Resource. The primary outcome was to interrogate the clinico-radiopathological correlates and prognostic indicators of stroke-like episode in patients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS). The secondary objective was to develop a multivariable pre2022-01-01T00:00:00Z2022 Apr2025-04-04T19:42:32.653Z2025-02-19T04:04:32.657ZS-EPMC90147383492767310.1093/brain/awab353