biostudies-literatureUnknown17(4)de Castro CT<h4>Background</h4>Paracetamol is widely used to manage fever and pain during pregnancy worldwide. However, paracetamol may affect the pregnant woman and fetus, once this drug crosses the placental barrier after therapeutic doses and may impair fetal liver function, affecting fetus growth and development. Thus, this study aimed to investigate the association between paracetamol use during pregnancy and perinatal outcomes as preterm birth, low birth weight, and small for gestational age.<h4>Methods and findings</h4>Data from 760 pregnant women within the NISAMI Cohort between June 2012 and February 2014 were analyzed. Logistic regression was used to estimate the association among paracetamol use during pregnancy and preterm birth, low birth weight, and small for gestational age. MultivariatPloS onee0267270https://www.ebi.ac.uk/biostudies/studies/S-EPMC9015137biostudies-literatureAssociation between paracetamol use during pregnancy and perinatal outcomes: Prospective NISAMI cohort.PMC9015137de Castro CTPereira MDos Santos DBfalseAssociation between paracetamol use during pregnancy and perinatal outcomes: Prospective NISAMI cohort.<h4>Background</h4>Paracetamol is widely used to manage fever and pain during pregnancy worldwide. However, paracetamol may affect the pregnant woman and fetus, once this drug crosses the placental barrier after therapeutic doses and may impair fetal liver function, affecting fetus growth and development. Thus, this study aimed to investigate the association between paracetamol use during pregnancy and perinatal outcomes as preterm birth, low birth weight, and small for gestational age.<h4>Methods and findings</h4>Data from 760 pregnant women within the NISAMI Cohort between June 2012 and February 2014 were analyzed. Logistic regression was used to estimate the association among paracetamol use during pregnancy and preterm birth, low birth weight, and small for gestational age. Multivariat2022-01-01T00:00:00Z20222025-04-04T19:42:15.114Z2025-04-04T19:42:15.114ZS-EPMC90151373543630810.1371/journal.pone.0267270