biostudies-literatureUnknown17(4)Hu G<h4>Background</h4>Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of baseline circulating platelet-to-lymphocyte ratio (PLR) (known as a marker of SIR) in human initial stage Ⅳ gastric cancer (GC) remains controversial. Hence, we performed this meta-analysis to assess the value of it in prognosis prediction for these patients.<h4>Materials and methods</h4>We searched PubMed, Embase and EBSCO to identify the studies and computed extracted data with STATA 12.0.<h4>Results</h4>A total of 3025 patients with initial stage Ⅳ GC from 13 published studies were incorporated into this meta-analysis. We found that elevated baseline circulating PLR was significantly associated with decreased overall survival (OPloS onee0265897https://www.ebi.ac.uk/biostudies/studies/S-EPMC9015147biostudies-literatureElevated baseline circulating platelet-to-lymphocyte ratio and survival in initial stage Ⅳ gastric cancer patients: A meta-analysis.PMC9015147Hu GWang SHuang LfalseElevated baseline circulating platelet-to-lymphocyte ratio and survival in initial stage Ⅳ gastric cancer patients: A meta-analysis.<h4>Background</h4>Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of baseline circulating platelet-to-lymphocyte ratio (PLR) (known as a marker of SIR) in human initial stage Ⅳ gastric cancer (GC) remains controversial. Hence, we performed this meta-analysis to assess the value of it in prognosis prediction for these patients.<h4>Materials and methods</h4>We searched PubMed, Embase and EBSCO to identify the studies and computed extracted data with STATA 12.0.<h4>Results</h4>A total of 3025 patients with initial stage Ⅳ GC from 13 published studies were incorporated into this meta-analysis. We found that elevated baseline circulating PLR was significantly associated with decreased overall survival (O2022-01-01T00:00:00Z20222025-04-04T20:37:02.565Z2025-04-04T20:37:02.565ZS-EPMC90151473543630510.1371/journal.pone.0265897